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000132784 0247_ $$2ISSN$$a1937-9145
000132784 0247_ $$2ISSN$$a1945-0877
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000132784 1001_ $$00000-0001-9905-7792$$aBabaei, Rohollah$$b0$$eFirst author
000132784 245__ $$aJak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.
000132784 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2018
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000132784 520__ $$aThe transient activation of inflammatory networks is required for adipose tissue remodeling including the 'browning' of white fat in response to stimuli such as β3-adrenergic receptor activation. In this process, white adipose tissue acquires thermogenic characteristics through the recruitment of so-called beige adipocytes. We investigated the downstream signaling pathways impinging on adipocyte progenitors that promote de novo formation of adipocytes. We showed that the Jak family of kinases controlled TGFβ signaling in the adipose tissue microenvironment through Stat3 and thereby adipogenic commitment, a function that was required for beige adipocyte differentiation of murine and human progenitors. Jak/Stat3 inhibited TGFβ signaling to the transcription factors Srf and Smad3 by repressing local Tgfb3 and Tgfb1 expression before the core transcriptional adipogenic cascade was activated. This pathway cross-talk was triggered in stromal cells by ATGL-dependent adipocyte lipolysis and a transient wave of IL-6 family cytokines at the onset of adipose tissue remodeling induced by β3-adrenergic receptor stimulation. Our results provide insight into the activation of adipocyte progenitors and are relevant for the therapeutic targeting of adipose tissue inflammatory pathways.
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000132784 7001_ $$00000-0001-9030-2210$$aSchuster, Maximilian$$b1
000132784 7001_ $$0P:(DE-He78)be839499b41c5f61b25e761622ba0a86$$aMeln, Irina$$b2$$udkfz
000132784 7001_ $$0P:(DE-He78)8f17e5ade9bb27444b5e417a0bd1c115$$aLerch, Sarah$$b3$$udkfz
000132784 7001_ $$00000-0002-5758-4292$$aGhandour, Rayane A$$b4
000132784 7001_ $$aPisani, Didier F$$b5
000132784 7001_ $$0P:(DE-He78)403b3fa7b66eb16193fff3acddeddcbd$$aBayindir-Buchhalter, Irem$$b6$$udkfz
000132784 7001_ $$0P:(DE-HGF)0$$aMarx, Julia$$b7
000132784 7001_ $$0P:(DE-He78)e57975a3de048070cbd23de65ac5776b$$aWu, Shuang$$b8$$udkfz
000132784 7001_ $$00000-0002-7346-2834$$aSchoiswohl, Gabriele$$b9
000132784 7001_ $$00000-0001-8724-4793$$aBilleter, Adrian T$$b10
000132784 7001_ $$0P:(DE-He78)2214defe87d04a849413e5eed47c415e$$aKrunic, Damir$$b11$$udkfz
000132784 7001_ $$00000-0002-0189-5876$$aMauer, Jan$$b12
000132784 7001_ $$aLee, Yun-Hee$$b13
000132784 7001_ $$aGranneman, James G$$b14
000132784 7001_ $$aFischer, Lars$$b15
000132784 7001_ $$00000-0002-8552-8538$$aMüller-Stich, Beat P$$b16
000132784 7001_ $$00000-0001-8426-5396$$aAmri, Ez-Zoubir$$b17
000132784 7001_ $$aKershaw, Erin E$$b18
000132784 7001_ $$0P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5$$aHeikenwälder, Mathias$$b19$$udkfz
000132784 7001_ $$aHerzig, Stephan$$b20
000132784 7001_ $$00000-0001-6300-316X$$aVegiopoulos, Alexandros$$b21$$eLast author
000132784 773__ $$0PERI:(DE-600)2417226-1$$a10.1126/scisignal.aai7838$$gVol. 11, no. 527, p. eaai7838 -$$n527$$peaai7838 -$$tScience signaling$$v11$$x1937-9145$$y2018
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