TY  - JOUR
AU  - Campa, Daniele
AU  - Barrdahl, Myrto
AU  - Santoro, Aurelia
AU  - Severi, Gianluca
AU  - Baglietto, Laura
AU  - Omichessan, Hanane
AU  - Tumino, Rosario
AU  - Bueno-de-Mesquita, H B As
AU  - Peeters, Petra H
AU  - Weiderpass, Elisabete
AU  - Chirlaque, Maria-Dolores
AU  - Rodríguez-Barranco, Miguel
AU  - Agudo, Antonio
AU  - Gunter, Marc
AU  - Dossus, Laure
AU  - Krogh, Vittorio
AU  - Matullo, Giuseppe
AU  - Trichopoulou, Antonia
AU  - Travis, Ruth C
AU  - Canzian, Federico
AU  - Kaaks, Rudolf
TI  - Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
JO  - Breast cancer research
VL  - 20
IS  - 1
SN  - 1465-542X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2018-00437
SP  - 29
PY  - 2018
AB  - Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number in up to 570 BC cases and 538 controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. As a first step, we measured LTL and mtDNA copy number in 96 individuals for which a blood sample had been collected twice with an interval of 15 years.According to the intraclass correlation (ICC), we found very good stability over the time period for both measurements, with ICCs of 0.63 for LTL and 0.60 for mtDNA copy number. In the analysis of the entire study sample, we observed that longer LTL was strongly associated with increased risk of BC (OR 2.71, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29665866
C2  - pmc:PMC5905156
DO  - DOI:10.1186/s13058-018-0955-5
UR  - https://inrepo02.dkfz.de/record/132793
ER  -