000132795 001__ 132795
000132795 005__ 20240229105032.0
000132795 0247_ $$2doi$$a10.1007/s10549-018-4666-5
000132795 0247_ $$2pmid$$apmid:29340881
000132795 0247_ $$2ISSN$$a0167-6806
000132795 0247_ $$2ISSN$$a1573-7217
000132795 037__ $$aDKFZ-2018-00439
000132795 041__ $$aeng
000132795 082__ $$a610
000132795 1001_ $$00000-0002-4772-0430$$aCheng, Jie$$b0$$eFirst author
000132795 245__ $$aCirculating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer.
000132795 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2018
000132795 3367_ $$2DRIVER$$aarticle
000132795 3367_ $$2DataCite$$aOutput Types/Journal article
000132795 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1552377176_25417
000132795 3367_ $$2BibTeX$$aARTICLE
000132795 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000132795 3367_ $$00$$2EndNote$$aJournal Article
000132795 520__ $$aNon-invasive blood-based molecular markers have been investigated for cancer diagnosis and prognosis. Circulating free or cell-free DNA (cfDNA) variables have been shown to be putative markers in breast cancer prognosis.Here, we investigated the potential prognostic ability of cfDNA concentration and cfDNA integrity (cfDI) in a study cohort of 268 patients by quantitative PCR. We compared cfDNA concentration and cfDI at baseline and after one cycle of therapy in metastatic breast cancer (MBC) patients.A significantly increased cfDI (P = 1.21E-7 for ALU and P = 1.87E-3 for LINE1) and decreased cfDNA concentration (P = 1.17E-3 for ALU and P = 1.60E-2 for LINE1) in both repetitive DNA elements after one cycle of therapy was observed. A multiple Cox regression model indicated that cfDI and cfDNA concentration can serve as independent prognostic markers in patients at baseline with HR (95% CI) of 0.70 (0.48-1.01) for ALU cfDI, 0.63 (0.44-0.92) for LINE1 cfDI, 2.44 (1.68-3.53) for ALU cfDNA concentration, and 2.12 (1.47-3.06) for LINE1 cfDNA concentration and after one cycle of therapy with HR (95% CI) of 0.59 (0.42-0.84) for ALU cfDI, 0.51 (0.36-0.74) for LINE1 cfDI, 1.59 (1.31-1.92) for ALU cfDNA concentration, and 1.30 (1.17-1.45) for LINE1 cfDNA concentration, respectively. By comparing integrated prediction error of different models, cfDNA variables were shown to improve the prognostic power of the CTC status.We hereby show that cfDNA variables, especially in combination with other markers, can serve as attractive prognostic markers for MBC patients at baseline and during the systematic therapy.
000132795 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000132795 588__ $$aDataset connected to CrossRef, PubMed,
000132795 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b1
000132795 7001_ $$aWallwiener, Markus$$b2
000132795 7001_ $$0P:(DE-He78)ec311cea9d07f894e44d05a570e26e28$$aSurowy, Harald$$b3
000132795 7001_ $$0P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a$$aCuk, Katarina$$b4
000132795 7001_ $$0P:(DE-He78)92c987a1eeee056d877629bfaaac5bc2$$aSchott, Sarah$$b5
000132795 7001_ $$0P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2$$aTrumpp, Andreas$$b6
000132795 7001_ $$aPantel, Klaus$$b7
000132795 7001_ $$aSohn, Christof$$b8
000132795 7001_ $$aSchneeweiss, Andreas$$b9
000132795 7001_ $$0P:(DE-He78)15b7fd2bc02d5ef47a2fe2dd0140d2bf$$aBurwinkel, Barbara$$b10$$eLast author
000132795 773__ $$0PERI:(DE-600)2004077-5$$a10.1007/s10549-018-4666-5$$gVol. 169, no. 1, p. 69 - 82$$n1$$p69 - 82$$tBreast cancer research and treatment$$v169$$x1573-7217$$y2018
000132795 909CO $$ooai:inrepo02.dkfz.de:132795$$pVDB
000132795 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-4772-0430$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ec311cea9d07f894e44d05a570e26e28$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)92c987a1eeee056d877629bfaaac5bc2$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000132795 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)15b7fd2bc02d5ef47a2fe2dd0140d2bf$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000132795 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000132795 9141_ $$y2018
000132795 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000132795 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBREAST CANCER RES TR : 2015
000132795 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000132795 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000132795 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000132795 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000132795 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000132795 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000132795 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000132795 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000132795 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000132795 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000132795 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000132795 9201_ $$0I:(DE-He78)C080-20160331$$kC080$$lMolekulare Epidemiologie$$x0
000132795 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lBiostatistik$$x1
000132795 9201_ $$0I:(DE-He78)A010-20160331$$kA010$$lStammzellen und Krebs$$x2
000132795 9201_ $$0I:(DE-He78)V960-20160331$$kV960$$lHI-Stem$$x3
000132795 980__ $$ajournal
000132795 980__ $$aVDB
000132795 980__ $$aI:(DE-He78)C080-20160331
000132795 980__ $$aI:(DE-He78)C060-20160331
000132795 980__ $$aI:(DE-He78)A010-20160331
000132795 980__ $$aI:(DE-He78)V960-20160331
000132795 980__ $$aUNRESTRICTED