TY  - JOUR
AU  - Cheng, Jie
AU  - Holland-Letz, Tim
AU  - Wallwiener, Markus
AU  - Surowy, Harald
AU  - Cuk, Katarina
AU  - Schott, Sarah
AU  - Trumpp, Andreas
AU  - Pantel, Klaus
AU  - Sohn, Christof
AU  - Schneeweiss, Andreas
AU  - Burwinkel, Barbara
TI  - Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer.
JO  - Breast cancer research and treatment
VL  - 169
IS  - 1
SN  - 1573-7217
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2018-00439
SP  - 69 - 82
PY  - 2018
AB  - Non-invasive blood-based molecular markers have been investigated for cancer diagnosis and prognosis. Circulating free or cell-free DNA (cfDNA) variables have been shown to be putative markers in breast cancer prognosis.Here, we investigated the potential prognostic ability of cfDNA concentration and cfDNA integrity (cfDI) in a study cohort of 268 patients by quantitative PCR. We compared cfDNA concentration and cfDI at baseline and after one cycle of therapy in metastatic breast cancer (MBC) patients.A significantly increased cfDI (P = 1.21E-7 for ALU and P = 1.87E-3 for LINE1) and decreased cfDNA concentration (P = 1.17E-3 for ALU and P = 1.60E-2 for LINE1) in both repetitive DNA elements after one cycle of therapy was observed. A multiple Cox regression model indicated that cfDI and cfDNA concentration can serve as independent prognostic markers in patients at baseline with HR (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29340881
DO  - DOI:10.1007/s10549-018-4666-5
UR  - https://inrepo02.dkfz.de/record/132795
ER  -