TY  - JOUR
AU  - Deike-Hofmann, Katerina
AU  - Thünemann, Daniel
AU  - Breckwoldt, Michael
AU  - Schwarz, Daniel
AU  - Radbruch, Alexander
AU  - Enk, Alexander
AU  - Bendszus, Martin
AU  - Hassel, Jessica
AU  - Schlemmer, Heinz-Peter
AU  - Bäumer, Philipp
TI  - Sensitivity of different MRI sequences in the early detection of melanoma brain metastases.
JO  - PLoS one
VL  - 13
IS  - 3
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2018-00441
SP  - e0193946 -
PY  - 2018
AB  - After the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was performed to investigate the sensitivity of six clinical MRI sequences in the early detection of MBM.Medical records of all melanoma patients referred to our center between November 2005 and December 2016 were reviewed for presence of MBM. Analysis encompassed six MRI sequences at the time of initial diagnosis of first or new MBM, including non-enhanced T1-weighted (T1w), contrast-enhanced T1w (ceT1w), T2-weighted (T2w), T2w-FLAIR, susceptibility-weighted (SWI) and diffusion-weighted (DWI) MRI. Each lesion was rated with respect to its conspicuity (score from 0-not detectable to 3-clearly visible).Of 1210 patients, 217 with MBM were included in the analysis and up to 5 lesions per patient were evaluated. A total of 720 metastases were assessed and all six sequences were available for 425 MBM. Sensitivity (conspicuity ≥2) was 99.7
LB  - PUB:(DE-HGF)16
C6  - pmid:29596475
C2  - pmc:PMC5875773
DO  - DOI:10.1371/journal.pone.0193946
UR  - https://inrepo02.dkfz.de/record/132797
ER  -