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@ARTICLE{Goerke:132808,
      author       = {S. Goerke$^*$ and J. Breitling$^*$ and M. Zaiss$^*$ and J.
                      Windschuh$^*$ and P. Kunz$^*$ and P. Schuenke and D.
                      Paech$^*$ and D. L. Longo and K. Klika$^*$ and M. Ladd$^*$
                      and P. Bachert$^*$},
      title        = {{D}ual-frequency irradiation {CEST}-{MRI} of endogenous
                      bulk mobile proteins.},
      journal      = {NMR in biomedicine},
      volume       = {N.N.},
      issn         = {0952-3480},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2018-00452},
      pages        = {e3920},
      year         = {2018},
      abstract     = {A novel MRI contrast is proposed which enables the
                      selective detection of endogenous bulk mobile proteins in
                      vivo. Such a non-invasive imaging technique may be of
                      particular interest for many diseases associated with
                      pathological alterations of protein expression, such as
                      cancer and neurodegenerative disorders. Specificity to
                      mobile proteins was achieved by the selective measurement of
                      intramolecular spin diffusion and the removal of semi-solid
                      macromolecular signal components by a correction procedure.
                      For this purpose, the approach of chemical exchange
                      saturation transfer (CEST) was extended to a radiofrequency
                      (RF) irradiation scheme at two different frequency offsets
                      (dualCEST). Using protein model solutions, it was
                      demonstrated that the dualCEST technique allows the
                      calculation of an image contrast which is exclusively
                      sensitive to changes in concentration, molecular size and
                      the folding state of mobile proteins. With respect to
                      application in humans, dualCEST overcomes the selectivity
                      limitations at relatively low magnetic field strengths, and
                      thus enables examinations on clinical MR scanners. The
                      feasibility of dualCEST examinations in humans was verified
                      by a proof-of-principle examination of a brain tumor patient
                      at 3 T. With its specificity for the mobile fraction of the
                      proteome, its comparable sensitivity to conventional water
                      proton MRI and its applicability to clinical MR scanners,
                      this technique represents a further step towards the
                      non-invasive imaging of proteomic changes in humans.},
      cin          = {E020 / B070 / E010 / G404},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)B070-20160331 /
                      I:(DE-He78)E010-20160331 / I:(DE-He78)G404-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29672976},
      doi          = {10.1002/nbm.3920},
      url          = {https://inrepo02.dkfz.de/record/132808},
}