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@ARTICLE{Horne:132818,
      author       = {H. N. Horne and H. Oh and M. E. Sherman and M. Palakal and
                      S. M. Hewitt and M. K. Schmidt and R. L. Milne and D.
                      Hardisson and J. Benitez and C. Blomqvist and M. K. Bolla
                      and H. Brenner$^*$ and J. Chang-Claude$^*$ and R. Cora and
                      F. J. Couch and K. Cuk$^*$ and P. Devilee and D. F. Easton
                      and D. M. Eccles and U. Eilber$^*$ and J. M. Hartikainen and
                      P. Heikkilä and B. Holleczek and M. J. Hooning and M. Jones
                      and R. Keeman and A. Mannermaa and J. W. M. Martens and T.
                      A. Muranen and H. Nevanlinna and J. E. Olson and N. Orr and
                      J. I. A. Perez and P. D. P. Pharoah and K. J. Ruddy and
                      K.-U. Saum$^*$ and M. J. Schoemaker and C. Seynaeve and R.
                      Sironen and V. T. H. B. M. Smit and A. J. Swerdlow and M.
                      Tengström and A. S. Thomas and A. M. Timmermans and R. A.
                      E. M. Tollenaar and M. A. Troester and C. J. van Asperen and
                      C. H. M. van Deurzen and F. F. Van Leeuwen and L. J. Van't
                      Veer and M. García-Closas and J. D. Figueroa},
      title        = {{E}-cadherin breast tumor expression, risk factors and
                      survival: {P}ooled analysis of 5,933 cases from 12 studies
                      in the {B}reast {C}ancer {A}ssociation {C}onsortium.},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2018-00462},
      pages        = {6574},
      year         = {2018},
      abstract     = {E-cadherin (CDH1) is a putative tumor suppressor gene
                      implicated in breast carcinogenesis. Yet, whether risk
                      factors or survival differ by E-cadherin tumor expression is
                      unclear. We evaluated E-cadherin tumor immunohistochemistry
                      expression using tissue microarrays of 5,933 female invasive
                      breast cancers from 12 studies from the Breast Cancer
                      Consortium. H-scores were calculated and case-case odds
                      ratios (OR) and $95\%$ confidence intervals (CIs) were
                      estimated using logistic regression. Survival analyses were
                      performed using Cox regression models. All analyses were
                      stratified by estrogen receptor (ER) status and histologic
                      subtype. E-cadherin low cases (N = 1191, $20\%)$ were
                      more frequently of lobular histology, low grade, >2 cm,
                      and HER2-negative. Loss of E-cadherin expression
                      (score < 100) was associated with menopausal hormone use
                      among ER-positive tumors (ever compared to never users,
                      OR = 1.24, $95\%$ CI = 0.97-1.59), which was
                      stronger when we evaluated complete loss of E-cadherin (i.e.
                      H-score = 0), OR = 1.57, $95\%$ CI = 1.06-2.33.
                      Breast cancer specific mortality was unrelated to E-cadherin
                      expression in multivariable models. E-cadherin low
                      expression is associated with lobular histology, tumor
                      characteristics and menopausal hormone use, with no evidence
                      of an association with breast cancer specific survival.
                      These data support loss of E-cadherin expression as an
                      important marker of tumor subtypes.},
      cin          = {C070 / G110 / C020 / L101},
      ddc          = {000},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29700408},
      pmc          = {pmc:PMC5920115},
      doi          = {10.1038/s41598-018-23733-4},
      url          = {https://inrepo02.dkfz.de/record/132818},
}