TY  - JOUR
AU  - Maalmi, Haifa
AU  - Walter, Viola
AU  - Jansen, Lina
AU  - Owen, Robert
AU  - Ulrich, Alexis
AU  - Schöttker, Ben
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Dose-Response Relationship between Serum Retinol Levels and Survival in Patients with Colorectal Cancer: Results from the DACHS Study.
JO  - Nutrients
VL  - 10
IS  - 4
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2018-00472
SP  - 510
PY  - 2018
AB  - Current knowledge on the role of retinol in the prognosis of patients with colorectal cancer (CRC) is very limited. We investigated the association of serum retinol levels with survival outcomes in a large cohort of 2908 CRC patients from Germany. Retinol concentrations were determined in serum collected shortly after diagnosis by mass spectrometry. Associations between serum retinol levels and survival outcomes were assessed using multivariable Cox regression and dose-response analyses. The joint association of serum retinol and serum 25-hydroxyvitamin D₃ (25(OH)D₃) with survival outcomes was also examined. During a median follow-up of 4.8 years, 787 deaths occurred, 573 of which were due to CRC. Dose-response curves showed an inverse relationship between serum retinol levels and survival endpoints in the range of <2.4 </td><td width="150">
AB  - micro;mol/L, but no associations at higher levels. Low (<1.2 </td><td width="150">
AB  - micro;mol/L) versus high (</td><td width="150">
AB  - ge;2.4 </td><td width="150">
AB  - micro;mol/L) serum retinol levels were associated with poorer overall survival (Hazard ratio (HR) = 1.46, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29671819
DO  - DOI:10.3390/nu10040510
UR  - https://inrepo02.dkfz.de/record/132828
ER  -