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@ARTICLE{Wild:132843,
      author       = {E. Wild$^*$ and D. Teber and D. Schmid$^*$ and T.
                      Simpfendörfer and M. Müller$^*$ and A.-C. Baranski$^*$ and
                      H. Kenngott and K. Kopka$^*$ and L. Maier-Hein$^*$},
      title        = {{R}obust augmented reality guidance with fluorescent
                      markers in laparoscopic surgery.},
      journal      = {International journal of computer assisted radiology and
                      surgery},
      volume       = {11},
      number       = {6},
      issn         = {1861-6429},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-00486},
      pages        = {899 - 907},
      year         = {2016},
      abstract     = {Laparoscopic interventions require the precise navigation
                      of medical instruments through the patient's body, while
                      taking critical structures into account. Although numerous
                      concepts have been proposed for displaying subsurface
                      anatomical detail using augmented reality, clinical
                      translation of these methods has suffered from a lack of
                      robustness as well as from cumbersome integration into the
                      clinical workflow. The purpose of this study was to
                      investigate the feasibility of a new approach to
                      intra-operative registration based on fluorescent
                      markers.The proposed approach to augmented reality
                      visualization relies on metabolizable fluorescent markers
                      that are attached to the target organ to guide a 2D/3D
                      intra-operative registration algorithm. In an ex vivo
                      porcine study, marker tracking performance is evaluated in
                      the presence of smoke, blood, and tissue in the field of
                      view of the endoscope.In contrast to state-of-the-art
                      needle-shaped fiducial markers, the fluorescent markers can
                      be reliably tracked when occluded by smoke, blood or tissue.
                      This makes the new 2D/3D intra-operative registration
                      approach considerably more robust than state-of-the-art
                      marker-based methods.As the concept can be smoothly
                      integrated into the clinical workflow, its potential for
                      application in clinical laparoscopy is high.},
      keywords     = {Coloring Agents (NLM Chemicals) / Indocyanine Green (NLM
                      Chemicals)},
      cin          = {E131 / E030},
      ddc          = {610},
      cid          = {I:(DE-He78)E131-20160331 / I:(DE-He78)E030-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27177759},
      doi          = {10.1007/s11548-016-1385-4},
      url          = {https://inrepo02.dkfz.de/record/132843},
}