TY  - JOUR
AU  - Obi, Nadia
AU  - Eulenburg, Christine
AU  - Seibold, Petra
AU  - Eilber, Ursula
AU  - Thöne, Kathrin
AU  - Behrens, Sabine
AU  - Chang-Claude, Jenny
AU  - Flesch-Janys, Dieter
TI  - Associations between adjuvant radiotherapy and different causes of death in a German breast cancer cohort.
JO  - The breast
VL  - 38
SN  - 0960-9776
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2018-00490
SP  - 75 - 80
PY  - 2018
AB  - Studies of cohorts of breast cancer (BC) patients diagnosed before 1990 showed radiotherapy (RT) to be associated with increased cardiovascular (CVD) and lung cancer mortality many years after diagnosis. In the late 1990s, improvements in RT planning techniques reduced radiation doses to normal tissues. Recent studies did not consistently report higher RT-related mortality for CVD and second cancers. Aim of the study was to analyze specific causes of death after 3D-conformal RT in a recent BC cohort.Stage I-III BC patients diagnosed 2001-2005 and enrolled in the population based MARIEplus study were followed-up for 11.9 years (median). Associations between adjuvant RT and cause-specific mortality were analyzed by using competing risks models, yielding subdistribution hazard ratios (SHR) for RT directly related to cumulative incidences. Models were adjusted for differences in baseline characteristics applying inverse-probability-of-treatment-weighting (IPTW).Of the 2951 patients, 2439 (83.0
LB  - PUB:(DE-HGF)16
C6  - pmid:29248876
DO  - DOI:10.1016/j.breast.2017.12.006
UR  - https://inrepo02.dkfz.de/record/132847
ER  -