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@ARTICLE{Thierauf:132862,
      author       = {J. Thierauf and S. E. Weissinger and J. A. Veit and A.
                      Affolter and N. K. Laureano$^*$ and D. Beutner and G.
                      Heiduschka and L. Kadletz and M. Meyer and A. Quaas and P.
                      Plinkert and T. K. Hoffmann and J. Hess$^*$},
      title        = {{L}ow {SOX}2 expression marks a distinct subset of adenoid
                      cystic carcinoma of the head and neck and is associated with
                      an advanced tumor stage.},
      journal      = {PLoS one},
      volume       = {13},
      number       = {3},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DKFZ-2018-00505},
      pages        = {e0194989 -},
      year         = {2018},
      abstract     = {The transcription factor SOX2 has been identified as a
                      lineage survival oncogene in squamous cell carcinoma and
                      copy number gain is a common event in several human
                      malignancies including head and neck cancer. However, the
                      regulation and function of SOX2 during carcinogenesis as
                      well as its prognostic value appears to be highly context
                      dependent. As an example, high SOX2 expression in lung
                      squamous cell carcinoma (SCC) is related to a favorable
                      prognosis, while it is associated with poor outcome in lung
                      adenocarcinoma. More recently, higher SOX2 levels and
                      improved survival was also reported for head and neck SCC
                      (HNSCC), and silencing of SOX2 expression in HNSCC cell
                      lines revealed a mesenchymal-like phenotype with prominent
                      vimentin expression. So far, SOX2 expression and its
                      clinical relevance for other head and neck cancers, such as
                      adenoid cystic carcinoma (HNACC) have not been sufficiently
                      investigated.SOX2, vimentin and E-cadherin expression was
                      assessed by immunohistochemical staining on serial sections
                      from formalin fixed and paraffin embedded tissue samples of
                      a patient cohort (n = 45) with primary ACC and correlated
                      with patient and tumor characteristics as well as
                      survival.High SOX2 expression was found in 14 $(31\%)$
                      primary tumor specimens and was significantly correlated
                      with a N0 lymph node status (p = 0.04), while low SOX2
                      expression was correlated with a solid growth pattern (p =
                      0.031). Of the 45 patients, 27 tumor samples resembled an
                      EMT-like phenotype, as assessed by high vimentin and low
                      E-cadherin levels. However, in HNACC SOX2 levels were
                      neither correlated with vimentin nor with E-cadherin
                      expression, further supporting a context dependent
                      regulation and function of SOX2 in distinct tumor
                      entities.The absence of SOX2 was predominantly found in
                      solid HNACC, which are characterized by a more aggressive
                      phenotype in ACC. However, the underlying molecular
                      mechanisms of SOX2 regulation and function in distinct HNACC
                      subgroups remain to be fully elucidated.},
      cin          = {G405},
      ddc          = {500},
      cid          = {I:(DE-He78)G405-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29596469},
      pmc          = {pmc:PMC5875788},
      doi          = {10.1371/journal.pone.0194989},
      url          = {https://inrepo02.dkfz.de/record/132862},
}