%0 Journal Article
%A Zhang, Yan
%A Saum, Kai-Uwe
%A Schöttker, Ben
%A Holleczek, Bernd
%A Brenner, Hermann
%T Methylomic survival predictors, frailty, and mortality.
%J Aging
%V 10
%N 3
%@ 1945-4589
%C [S.l.]
%I Impact Journals, LLC
%M DKFZ-2018-00519
%P 339-357
%D 2018
%X Survival predictors are of potential use for informing on biological age and targeting prevention of aging-related morbidity. We assessed associations of 2 novel methylomic survival indicators, a methylation-based mortality risk score (MRscore) and the epigenetic clock-derived age acceleration (AA), with a well-known survival predictor, frailty index (FI), and compared the 3 indicators in mortality prediction. In a large population-based cohort with 14-year follow-up, we found both MRscore and AA to be independently associated with FI, but the association was much stronger for MRscore than for AA. Although all 3 indicators were individually associated with all-cause mortality, robust associations only persisted for MRscore and FI when simultaneously including the 3 indicators in regression models, with hazard ratios (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29514134
%2 pmc:PMC5892685
%R 10.18632/aging.101392
%U https://inrepo02.dkfz.de/record/132877