TY  - JOUR
AU  - Zhang, Yan
AU  - Saum, Kai-Uwe
AU  - Schöttker, Ben
AU  - Holleczek, Bernd
AU  - Brenner, Hermann
TI  - Methylomic survival predictors, frailty, and mortality.
JO  - Aging
VL  - 10
IS  - 3
SN  - 1945-4589
CY  - [S.l.]
PB  - Impact Journals, LLC
M1  - DKFZ-2018-00519
SP  - 339-357
PY  - 2018
AB  - Survival predictors are of potential use for informing on biological age and targeting prevention of aging-related morbidity. We assessed associations of 2 novel methylomic survival indicators, a methylation-based mortality risk score (MRscore) and the epigenetic clock-derived age acceleration (AA), with a well-known survival predictor, frailty index (FI), and compared the 3 indicators in mortality prediction. In a large population-based cohort with 14-year follow-up, we found both MRscore and AA to be independently associated with FI, but the association was much stronger for MRscore than for AA. Although all 3 indicators were individually associated with all-cause mortality, robust associations only persisted for MRscore and FI when simultaneously including the 3 indicators in regression models, with hazard ratios (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29514134
C2  - pmc:PMC5892685
DO  - DOI:10.18632/aging.101392
UR  - https://inrepo02.dkfz.de/record/132877
ER  -