000132887 001__ 132887
000132887 005__ 20240229105037.0
000132887 0247_ $$2doi$$a10.3389/fimmu.2018.00813
000132887 0247_ $$2pmid$$apmid:29720980
000132887 0247_ $$2pmc$$apmc:PMC5915482
000132887 0247_ $$2altmetric$$aaltmetric:40705932
000132887 037__ $$aDKFZ-2018-00529
000132887 041__ $$aeng
000132887 082__ $$a610
000132887 1001_ $$0P:(DE-He78)70e630b77e8ddc41353fc23197569b7c$$aKordass, Theresa$$b0$$eFirst author$$udkfz
000132887 245__ $$aControlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E.
000132887 260__ $$aLausanne$$bFrontiers Media$$c2018
000132887 3367_ $$2DRIVER$$aarticle
000132887 3367_ $$2DataCite$$aOutput Types/Journal article
000132887 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1526386348_14695$$xReview Article
000132887 3367_ $$2BibTeX$$aARTICLE
000132887 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000132887 3367_ $$00$$2EndNote$$aJournal Article
000132887 520__ $$aThe NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory immune checkpoint molecule, since free adenosine generated by NT5E inhibits cellular immune responses, thereby promoting immune escape of tumor cells. MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression on posttranscriptional level through binding to mRNAs, resulting in translational repression or degradation of the targeted mRNA molecule. In tumor cells, miRNA expression patterns are often altered which in turn might affect NT5E surface expression and eventually influence the efficacy of antitumor immune responses. This review describes the diverse roles of NT5E, summarizes current knowledge about transcription factors controlling NT5E expression, and highlights the significance of miRNAs involved in the posttranscriptional regulation of NT5E expression.
000132887 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000132887 588__ $$aDataset connected to CrossRef, PubMed,
000132887 7001_ $$0P:(DE-He78)b757b21d60bbaa4164899bb7e61b0c15$$aOsen, Wolfram$$b1$$udkfz
000132887 7001_ $$0P:(DE-He78)23fb8cfffbf2aa8eee5d51af417ad944$$aEichmüller, Stefan$$b2$$eLast author$$udkfz
000132887 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2018.00813$$gVol. 9, p. 813$$p813$$tFrontiers in immunology$$v9$$x1664-3224$$y2018
000132887 909CO $$ooai:inrepo02.dkfz.de:132887$$pVDB
000132887 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)70e630b77e8ddc41353fc23197569b7c$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000132887 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b757b21d60bbaa4164899bb7e61b0c15$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000132887 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)23fb8cfffbf2aa8eee5d51af417ad944$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000132887 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000132887 9141_ $$y2018
000132887 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT IMMUNOL : 2015
000132887 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000132887 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000132887 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000132887 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000132887 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000132887 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000132887 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000132887 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000132887 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000132887 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bFRONT IMMUNOL : 2015
000132887 9201_ $$0I:(DE-He78)G182-20160331$$kG182$$lGMP Einheit  Zelluläre Therapie$$x0
000132887 980__ $$ajournal
000132887 980__ $$aVDB
000132887 980__ $$aI:(DE-He78)G182-20160331
000132887 980__ $$aUNRESTRICTED