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@ARTICLE{Kordass:132887,
      author       = {T. Kordass$^*$ and W. Osen$^*$ and S. Eichmüller$^*$},
      title        = {{C}ontrolling the {I}mmune {S}uppressor: {T}ranscription
                      {F}actors and {M}icro{RNA}s {R}egulating {CD}73/{NT}5{E}.},
      journal      = {Frontiers in immunology},
      volume       = {9},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2018-00529},
      pages        = {813},
      year         = {2018},
      abstract     = {The NT5E (CD73) molecule represents an ecto-5'-nucleotidase
                      expressed on the cell surface of various cell types.
                      Hydrolyzing extracellular adenosine monophosphate into
                      adenosine and inorganic phosphate, NT5E performs numerous
                      homeostatic functions in healthy organs and tissues.
                      Importantly, NT5E can act as inhibitory immune checkpoint
                      molecule, since free adenosine generated by NT5E inhibits
                      cellular immune responses, thereby promoting immune escape
                      of tumor cells. MicroRNAs (miRNAs) are small non-coding RNA
                      molecules regulating gene expression on posttranscriptional
                      level through binding to mRNAs, resulting in translational
                      repression or degradation of the targeted mRNA molecule. In
                      tumor cells, miRNA expression patterns are often altered
                      which in turn might affect NT5E surface expression and
                      eventually influence the efficacy of antitumor immune
                      responses. This review describes the diverse roles of NT5E,
                      summarizes current knowledge about transcription factors
                      controlling NT5E expression, and highlights the significance
                      of miRNAs involved in the posttranscriptional regulation of
                      NT5E expression.},
      subtyp        = {Review Article},
      cin          = {G182},
      ddc          = {610},
      cid          = {I:(DE-He78)G182-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29720980},
      pmc          = {pmc:PMC5915482},
      doi          = {10.3389/fimmu.2018.00813},
      url          = {https://inrepo02.dkfz.de/record/132887},
}