%0 Journal Article
%A Meidtner, Karina
%A Podmore, Clara
%A Kröger, Janine
%A van der Schouw, Yvonne T
%A Bendinelli, Benedetta
%A Agnoli, Claudia
%A Arriola, Larraitz
%A Barricarte, Aurelio
%A Boeing, Heiner
%A Cross, Amanda J
%A Dow, Courtney
%A Ekblom, Kim
%A Fagherazzi, Guy
%A Franks, Paul W
%A Gunter, Marc J
%A Huerta, José María
%A Jakszyn, Paula
%A Jenab, Mazda
%A Katzke, Verena
%A Key, Timothy J
%A Khaw, Kay Tee
%A Kühn, Tilman
%A Kyrø, Cecilie
%A Mancini, Francesca Romana
%A Melander, Olle
%A Nilsson, Peter M
%A Overvad, Kim
%A Palli, Domenico
%A Panico, Salvatore
%A Quirós, J Ramón
%A Rodríguez-Barranco, Miguel
%A Sacerdote, Carlotta
%A Sluijs, Ivonne
%A Stepien, Magdalena
%A Tjonneland, Anne
%A Tumino, Rosario
%A Forouhi, Nita G
%A Sharp, Stephen J
%A Langenberg, Claudia
%A Schulze, Matthias B
%A Riboli, Elio
%A Wareham, Nicholas J
%T Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
%J Diabetes care
%V 41
%N 2
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2018-00535
%P 277 - 285
%D 2018
%X Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29167213
%R 10.2337/dc17-1080
%U https://inrepo02.dkfz.de/record/132893