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000132893 041__ $$aeng
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000132893 1001_ $$aMeidtner, Karina$$b0
000132893 245__ $$aInteraction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
000132893 260__ $$aAlexandria, Va.$$bAssoc.$$c2018
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000132893 520__ $$aMeat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
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000132893 7001_ $$00000-0002-2452-8067$$aPodmore, Clara$$b1
000132893 7001_ $$00000-0002-7496-3665$$aKröger, Janine$$b2
000132893 7001_ $$avan der Schouw, Yvonne T$$b3
000132893 7001_ $$aBendinelli, Benedetta$$b4
000132893 7001_ $$aAgnoli, Claudia$$b5
000132893 7001_ $$aArriola, Larraitz$$b6
000132893 7001_ $$aBarricarte, Aurelio$$b7
000132893 7001_ $$aBoeing, Heiner$$b8
000132893 7001_ $$aCross, Amanda J$$b9
000132893 7001_ $$aDow, Courtney$$b10
000132893 7001_ $$aEkblom, Kim$$b11
000132893 7001_ $$00000-0001-5033-5966$$aFagherazzi, Guy$$b12
000132893 7001_ $$00000-0002-0520-7604$$aFranks, Paul W$$b13
000132893 7001_ $$aGunter, Marc J$$b14
000132893 7001_ $$aHuerta, José María$$b15
000132893 7001_ $$aJakszyn, Paula$$b16
000132893 7001_ $$aJenab, Mazda$$b17
000132893 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b18
000132893 7001_ $$aKey, Timothy J$$b19
000132893 7001_ $$aKhaw, Kay Tee$$b20
000132893 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b21$$udkfz
000132893 7001_ $$aKyrø, Cecilie$$b22
000132893 7001_ $$aMancini, Francesca Romana$$b23
000132893 7001_ $$aMelander, Olle$$b24
000132893 7001_ $$aNilsson, Peter M$$b25
000132893 7001_ $$aOvervad, Kim$$b26
000132893 7001_ $$aPalli, Domenico$$b27
000132893 7001_ $$aPanico, Salvatore$$b28
000132893 7001_ $$aQuirós, J Ramón$$b29
000132893 7001_ $$aRodríguez-Barranco, Miguel$$b30
000132893 7001_ $$aSacerdote, Carlotta$$b31
000132893 7001_ $$aSluijs, Ivonne$$b32
000132893 7001_ $$aStepien, Magdalena$$b33
000132893 7001_ $$aTjonneland, Anne$$b34
000132893 7001_ $$aTumino, Rosario$$b35
000132893 7001_ $$00000-0002-5041-248X$$aForouhi, Nita G$$b36
000132893 7001_ $$aSharp, Stephen J$$b37
000132893 7001_ $$aLangenberg, Claudia$$b38
000132893 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b39
000132893 7001_ $$aRiboli, Elio$$b40
000132893 7001_ $$aWareham, Nicholas J$$b41
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