TY  - JOUR
AU  - Meidtner, Karina
AU  - Podmore, Clara
AU  - Kröger, Janine
AU  - van der Schouw, Yvonne T
AU  - Bendinelli, Benedetta
AU  - Agnoli, Claudia
AU  - Arriola, Larraitz
AU  - Barricarte, Aurelio
AU  - Boeing, Heiner
AU  - Cross, Amanda J
AU  - Dow, Courtney
AU  - Ekblom, Kim
AU  - Fagherazzi, Guy
AU  - Franks, Paul W
AU  - Gunter, Marc J
AU  - Huerta, José María
AU  - Jakszyn, Paula
AU  - Jenab, Mazda
AU  - Katzke, Verena
AU  - Key, Timothy J
AU  - Khaw, Kay Tee
AU  - Kühn, Tilman
AU  - Kyrø, Cecilie
AU  - Mancini, Francesca Romana
AU  - Melander, Olle
AU  - Nilsson, Peter M
AU  - Overvad, Kim
AU  - Palli, Domenico
AU  - Panico, Salvatore
AU  - Quirós, J Ramón
AU  - Rodríguez-Barranco, Miguel
AU  - Sacerdote, Carlotta
AU  - Sluijs, Ivonne
AU  - Stepien, Magdalena
AU  - Tjonneland, Anne
AU  - Tumino, Rosario
AU  - Forouhi, Nita G
AU  - Sharp, Stephen J
AU  - Langenberg, Claudia
AU  - Schulze, Matthias B
AU  - Riboli, Elio
AU  - Wareham, Nicholas J
TI  - Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
JO  - Diabetes care
VL  - 41
IS  - 2
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2018-00535
SP  - 277 - 285
PY  - 2018
AB  - Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:29167213
DO  - DOI:10.2337/dc17-1080
UR  - https://inrepo02.dkfz.de/record/132893
ER  -