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@ARTICLE{Meidtner:132893,
      author       = {K. Meidtner and C. Podmore and J. Kröger and Y. T. van der
                      Schouw and B. Bendinelli and C. Agnoli and L. Arriola and A.
                      Barricarte and H. Boeing and A. J. Cross and C. Dow and K.
                      Ekblom and G. Fagherazzi and P. W. Franks and M. J. Gunter
                      and J. M. Huerta and P. Jakszyn and M. Jenab and V.
                      Katzke$^*$ and T. J. Key and K. T. Khaw and T. Kühn$^*$ and
                      C. Kyrø and F. R. Mancini and O. Melander and P. M. Nilsson
                      and K. Overvad and D. Palli and S. Panico and J. R. Quirós
                      and M. Rodríguez-Barranco and C. Sacerdote and I. Sluijs
                      and M. Stepien and A. Tjonneland and R. Tumino and N. G.
                      Forouhi and S. J. Sharp and C. Langenberg and M. B. Schulze
                      and E. Riboli and N. J. Wareham},
      title        = {{I}nteraction of {D}ietary and {G}enetic {F}actors
                      {I}nfluencing {B}ody {I}ron {S}tatus and {R}isk of {T}ype 2
                      {D}iabetes {W}ithin the {EPIC}-{I}nter{A}ct {S}tudy.},
      journal      = {Diabetes care},
      volume       = {41},
      number       = {2},
      issn         = {1935-5548},
      address      = {Alexandria, Va.},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2018-00535},
      pages        = {277 - 285},
      year         = {2018},
      abstract     = {Meat intake has been consistently shown to be positively
                      associated with incident type 2 diabetes. Part of that
                      association may be mediated by body iron status, which is
                      influenced by genetic factors. We aimed to test for
                      interactions of genetic and dietary factors influencing body
                      iron status in relation to the risk of incident type 2
                      diabetes.The case-cohort comprised 9,347 case subjects and
                      12,301 subcohort participants from eight European countries.
                      Single nucleotide polymorphisms (SNPs) were selected from
                      genome-wide association studies on iron status biomarkers
                      and candidate gene studies. A ferritin-related gene score
                      was constructed. Multiplicative and additive interactions of
                      heme iron and SNPs as well as the gene score were evaluated
                      using Cox proportional hazards regression.Higher heme iron
                      intake (per 1 SD) was associated with higher ferritin levels
                      (β = 0.113 $[95\%$ CI 0.082; 0.144]), but not with
                      transferrin (-0.019 [-0.043; 0.006]) or transferrin
                      saturation (0.016 [-0.006; 0.037]). Five SNPs located in
                      four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y],
                      rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6
                      V736A]) were associated with ferritin. We did not detect an
                      interaction of heme iron and the gene score on the risk of
                      diabetes in the overall study population (Padd = 0.16, Pmult
                      = 0.21) but did detect a trend toward a negative interaction
                      in men (Padd = 0.04, Pmult = 0.03).We found no convincing
                      evidence that the interplay of dietary and genetic factors
                      related to body iron status associates with type 2 diabetes
                      risk above the level expected from the sum or product of the
                      two individual exposures.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29167213},
      doi          = {10.2337/dc17-1080},
      url          = {https://inrepo02.dkfz.de/record/132893},
}