%0 Journal Article
%A Niedermaier, Tobias
%A Weigl, Korbinian
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Diagnostic Performance of One-off Flexible Sigmoidoscopy with Fecal Immunochemical Testing in a Large Screening Population.
%J Epidemiology
%V 29
%N 3
%@ 1044-3983
%C Philadelphia, Pa.
%I Lippincott Williams & Wilkins
%M DKFZ-2018-00538
%P 397 - 406
%D 2018
%X Flexible sigmoidoscopy and fecal immunochemical tests are established diagnostic tests for colorectal cancer (CRC) screening and less invasive, less expensive, and easier to conduct than colonoscopy. However, little is known about their joint diagnostic performance compared with colonoscopy. We aimed to assess the expected diagnostic performance of joint use of flexible sigmoidoscopy and fecal immunochemical test.We assessed the overall and site-specific prevalences of colorectal neoplasms and the overall sensitivity, specificity, area under the receiver operating characteristics curve of a quantitative fecal immunochemical test (FOB Gold, Sentinel Diagnostics, Milano, Italy) among 3,466 participants in screening colonoscopy in Germany. Results were used to model the expected diagnostic performance of joint use of flexible sigmoidoscopy and fecal immunochemical testing.CRC and advanced adenomas were found in 29 (1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29287053
%R 10.1097/EDE.0000000000000795
%U https://inrepo02.dkfz.de/record/132896