TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Weigl, Korbinian
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Diagnostic Performance of One-off Flexible Sigmoidoscopy with Fecal Immunochemical Testing in a Large Screening Population.
JO  - Epidemiology
VL  - 29
IS  - 3
SN  - 1044-3983
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DKFZ-2018-00538
SP  - 397 - 406
PY  - 2018
AB  - Flexible sigmoidoscopy and fecal immunochemical tests are established diagnostic tests for colorectal cancer (CRC) screening and less invasive, less expensive, and easier to conduct than colonoscopy. However, little is known about their joint diagnostic performance compared with colonoscopy. We aimed to assess the expected diagnostic performance of joint use of flexible sigmoidoscopy and fecal immunochemical test.We assessed the overall and site-specific prevalences of colorectal neoplasms and the overall sensitivity, specificity, area under the receiver operating characteristics curve of a quantitative fecal immunochemical test (FOB Gold, Sentinel Diagnostics, Milano, Italy) among 3,466 participants in screening colonoscopy in Germany. Results were used to model the expected diagnostic performance of joint use of flexible sigmoidoscopy and fecal immunochemical testing.CRC and advanced adenomas were found in 29 (1
LB  - PUB:(DE-HGF)16
C6  - pmid:29287053
DO  - DOI:10.1097/EDE.0000000000000795
UR  - https://inrepo02.dkfz.de/record/132896
ER  -