% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Niedermaier:132896,
      author       = {T. Niedermaier$^*$ and K. Weigl$^*$ and M. Hoffmeister$^*$
                      and H. Brenner$^*$},
      title        = {{D}iagnostic {P}erformance of {O}ne-off {F}lexible
                      {S}igmoidoscopy with {F}ecal {I}mmunochemical {T}esting in a
                      {L}arge {S}creening {P}opulation.},
      journal      = {Epidemiology},
      volume       = {29},
      number       = {3},
      issn         = {1044-3983},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2018-00538},
      pages        = {397 - 406},
      year         = {2018},
      abstract     = {Flexible sigmoidoscopy and fecal immunochemical tests are
                      established diagnostic tests for colorectal cancer (CRC)
                      screening and less invasive, less expensive, and easier to
                      conduct than colonoscopy. However, little is known about
                      their joint diagnostic performance compared with
                      colonoscopy. We aimed to assess the expected diagnostic
                      performance of joint use of flexible sigmoidoscopy and fecal
                      immunochemical test.We assessed the overall and
                      site-specific prevalences of colorectal neoplasms and the
                      overall sensitivity, specificity, area under the receiver
                      operating characteristics curve of a quantitative fecal
                      immunochemical test (FOB Gold, Sentinel Diagnostics, Milano,
                      Italy) among 3,466 participants in screening colonoscopy in
                      Germany. Results were used to model the expected diagnostic
                      performance of joint use of flexible sigmoidoscopy and fecal
                      immunochemical testing.CRC and advanced adenomas were found
                      in 29 $(1\%)$ and 354 $(10\%)$ participants, respectively.
                      The area under the curve of fecal immunochemical testing for
                      these outcomes could be raised from $96\%$ to $100\%$ and
                      from $70\%$ to $89\%,$ respectively, by combining it with
                      flexible sigmoidoscopy. At $90\%$ specificity, sensitivity
                      of fecal immunochemical testing would increase from $97\%$
                      to $100\%$ for CRC and from $40\%$ to $79\%$ for advanced
                      adenomas.Combining flexible sigmoidoscopy and fecal
                      immunochemical testing might strongly enhance diagnostic
                      performance of each single test to a level close to the
                      diagnostic performance of screening colonoscopy while
                      avoiding many unnecessary colonoscopies.},
      cin          = {C070 / L101 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)G110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29287053},
      doi          = {10.1097/EDE.0000000000000795},
      url          = {https://inrepo02.dkfz.de/record/132896},
}