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000132908 0247_ $$2doi$$a10.1007/s00259-018-3940-4
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000132908 0247_ $$2ISSN$$a0340-6997
000132908 0247_ $$2ISSN$$a1432-105X
000132908 0247_ $$2ISSN$$a1619-7070
000132908 0247_ $$2ISSN$$a1619-7089
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000132908 037__ $$aDKFZ-2018-00550
000132908 041__ $$aeng
000132908 082__ $$a610
000132908 1001_ $$ada Silva, N. A.$$b0
000132908 245__ $$aHybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI.
000132908 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2018
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000132908 520__ $$aPET using radiolabelled amino acids has become a promising tool in the diagnostics of gliomas and brain metastasis. Current research is focused on the evaluation of amide proton transfer (APT) chemical exchange saturation transfer (CEST) MR imaging for brain tumour imaging. In this hybrid MR-PET study, brain tumours were compared using 3D data derived from APT-CEST MRI and amino acid PET using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET).Eight patients with gliomas were investigated simultaneously with 18F-FET PET and APT-CEST MRI using a 3-T MR-BrainPET scanner. CEST imaging was based on a steady-state approach using a B1 average power of 1μT. B0 field inhomogeneities were corrected a Prametric images of magnetisation transfer ratio asymmetry (MTRasym) and differences to the extrapolated semi-solid magnetisation transfer reference method, APT# and nuclear Overhauser effect (NOE#), were calculated. Statistical analysis of the tumour-to-brain ratio of the CEST data was performed against PET data using the non-parametric Wilcoxon test.A tumour-to-brain ratio derived from APT# and 18F-FET presented no significant differences, and no correlation was found between APT# and 18F-FET PET data. The distance between local hot spot APT# and 18F-FET were different (average 20 ± 13 mm, range 4-45 mm).For the first time, CEST images were compared with 18F-FET in a simultaneous MR-PET measurement. Imaging findings derived from18F-FET PET and APT CEST MRI seem to provide different biological information. The validation of these imaging findings by histological confirmation is necessary, ideally using stereotactic biopsy.
000132908 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
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000132908 7001_ $$aLohmann, P.$$b1
000132908 7001_ $$aFairney, J.$$b2
000132908 7001_ $$0P:(DE-He78)5ceba3ebae6ecd5e27fa39a0365ff08e$$aMagill, Arthur$$b3$$udkfz
000132908 7001_ $$aOros Peusquens, A-M$$b4
000132908 7001_ $$aChoi, C-H$$b5
000132908 7001_ $$aStirnberg, R.$$b6
000132908 7001_ $$aStoffels, G.$$b7
000132908 7001_ $$aGalldiks, N.$$b8
000132908 7001_ $$aGolay, X.$$b9
000132908 7001_ $$aLangen, K-J$$b10
000132908 7001_ $$aJon Shah, N.$$b11
000132908 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-018-3940-4$$gVol. 45, no. 6, p. 1031 - 1040$$n6$$p1031 - 1040$$tEuropean journal of nuclear medicine and molecular imaging$$v45$$x1619-7089$$y2018
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000132908 9141_ $$y2018
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