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@ARTICLE{daSilva:132908,
      author       = {N. A. da Silva and P. Lohmann and J. Fairney and A.
                      Magill$^*$ and A.-M. Oros Peusquens and C.-H. Choi and R.
                      Stirnberg and G. Stoffels and N. Galldiks and X. Golay and
                      K.-J. Langen and N. Jon Shah},
      title        = {{H}ybrid {MR}-{PET} of brain tumours using amino acid {PET}
                      and chemical exchange saturation transfer {MRI}.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {45},
      number       = {6},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2018-00550},
      pages        = {1031 - 1040},
      year         = {2018},
      abstract     = {PET using radiolabelled amino acids has become a promising
                      tool in the diagnostics of gliomas and brain metastasis.
                      Current research is focused on the evaluation of amide
                      proton transfer (APT) chemical exchange saturation transfer
                      (CEST) MR imaging for brain tumour imaging. In this hybrid
                      MR-PET study, brain tumours were compared using 3D data
                      derived from APT-CEST MRI and amino acid PET using
                      O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET).Eight patients
                      with gliomas were investigated simultaneously with 18F-FET
                      PET and APT-CEST MRI using a 3-T MR-BrainPET scanner. CEST
                      imaging was based on a steady-state approach using a B1
                      average power of 1μT. B0 field inhomogeneities were
                      corrected a Prametric images of magnetisation transfer ratio
                      asymmetry (MTRasym) and differences to the extrapolated
                      semi-solid magnetisation transfer reference method, APT# and
                      nuclear Overhauser effect (NOE#), were calculated.
                      Statistical analysis of the tumour-to-brain ratio of the
                      CEST data was performed against PET data using the
                      non-parametric Wilcoxon test.A tumour-to-brain ratio derived
                      from APT# and 18F-FET presented no significant differences,
                      and no correlation was found between APT# and 18F-FET PET
                      data. The distance between local hot spot APT# and 18F-FET
                      were different (average 20 ± 13 mm, range
                      4-45 mm).For the first time, CEST images were compared with
                      18F-FET in a simultaneous MR-PET measurement. Imaging
                      findings derived from18F-FET PET and APT CEST MRI seem to
                      provide different biological information. The validation
                      of these imaging findings by histological confirmation is
                      necessary, ideally using stereotactic biopsy.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29478081},
      doi          = {10.1007/s00259-018-3940-4},
      url          = {https://inrepo02.dkfz.de/record/132908},
}