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@ARTICLE{Benzel:132932,
author = {J. Benzel$^*$ and V. Fendrich},
title = {{C}hemoprevention and {T}reatment of {P}ancreatic {C}ancer:
{U}pdate and {R}eview of the {L}iterature.},
journal = {Digestion},
volume = {97},
number = {4},
issn = {1421-9867},
address = {Basel},
publisher = {Karger},
reportid = {DKFZ-2018-00571},
pages = {275 - 287},
year = {2018},
abstract = {Pancreatic ductal adenocarcinoma is one of the most lethal
types of cancer with a 5-year survival rate of around $7\%.$
Due to the relatively poor prognosis, the potential need of
an effective chemoprevention is highly needed.Different risk
factors like smoking or hereditary tumour syndromes should
be known for early detection of pancreatic intraepithelial
neoplasia. Chemopreventive dietary agents include curcumin,
capsaicin and flavonoid, whereas potential chemopreventive
drugs compromise aspirin, metformin or statins. This review
aims to give an overview on potential risk factors for the
development of pancreatic cancer. Furthermore, we try to
summarise known chemopreventive agents to support the fight
against this lethal disease. Key Messages: On the one hand,
there are natural agents that exhibit preventive properties
and can lead to the prohibition of pancreatic cancer. On the
other hand, there are drugs and agents that are currently
used in other contexts and are thus already approved and
studied in terms of their mechanisms of effects and the
related secondary effects.},
subtyp = {Review Article},
cin = {B062},
ddc = {610},
cid = {I:(DE-He78)B062-20160331},
pnm = {312 - Functional and structural genomics (POF3-312)},
pid = {G:(DE-HGF)POF3-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29587290},
doi = {10.1159/000485741},
url = {https://inrepo02.dkfz.de/record/132932},
}