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@ARTICLE{Benzel:132932,
      author       = {J. Benzel$^*$ and V. Fendrich},
      title        = {{C}hemoprevention and {T}reatment of {P}ancreatic {C}ancer:
                      {U}pdate and {R}eview of the {L}iterature.},
      journal      = {Digestion},
      volume       = {97},
      number       = {4},
      issn         = {1421-9867},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DKFZ-2018-00571},
      pages        = {275 - 287},
      year         = {2018},
      abstract     = {Pancreatic ductal adenocarcinoma is one of the most lethal
                      types of cancer with a 5-year survival rate of around $7\%.$
                      Due to the relatively poor prognosis, the potential need of
                      an effective chemoprevention is highly needed.Different risk
                      factors like smoking or hereditary tumour syndromes should
                      be known for early detection of pancreatic intraepithelial
                      neoplasia. Chemopreventive dietary agents include curcumin,
                      capsaicin and flavonoid, whereas potential chemopreventive
                      drugs compromise aspirin, metformin or statins. This review
                      aims to give an overview on potential risk factors for the
                      development of pancreatic cancer. Furthermore, we try to
                      summarise known chemopreventive agents to support the fight
                      against this lethal disease. Key Messages: On the one hand,
                      there are natural agents that exhibit preventive properties
                      and can lead to the prohibition of pancreatic cancer. On the
                      other hand, there are drugs and agents that are currently
                      used in other contexts and are thus already approved and
                      studied in terms of their mechanisms of effects and the
                      related secondary effects.},
      subtyp        = {Review Article},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29587290},
      doi          = {10.1159/000485741},
      url          = {https://inrepo02.dkfz.de/record/132932},
}