TY  - JOUR
AU  - Carr, Prudence
AU  - Alwers, E.
AU  - Bienert, S.
AU  - Weberpals, J.
AU  - Kloor, M.
AU  - Brenner, H.
AU  - Hoffmeister, Michael
TI  - Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses.
JO  - Annals of oncology
VL  - 29
IS  - 4
SN  - 1569-8041
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-00574
SP  - 825 - 834
PY  - 2018
AB  - The association of lifestyle factors with molecular pathological subtypes of colorectal cancer (CRC), such as microsatellite instability (MSI), could provide further knowledge about the colorectal carcinogenic process. The aim of this review was to evaluate possible associations between lifestyle factors and risk of sporadic CRC by MSI status.PubMed and Web of Science were searched for studies investigating the association between alcohol, body mass index, dietary fiber, hormone replacement therapy (HRT), non-steroidal anti-inflammatory drugs, physical activity, red meat, smoking, or statin use, with MSI-high (MSI-H) and microsatellite stable (MSS) CRC. Meta-analyses were carried out to calculate summary relative risks (sRR).Overall, 31 studies reporting on the association between lifestyle factors and CRC according to MSI status were included in this review. Ever smoking was associated with MSI-H (sRR = 1.62; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29438474
DO  - DOI:10.1093/annonc/mdy059
UR  - https://inrepo02.dkfz.de/record/132935
ER  -