%0 Journal Article
%A Li, Sherly X
%A Imamura, Fumiaki
%A Schulze, Matthias B
%A Zheng, Jusheng
%A Ye, Zheng
%A Agudo, Antonio
%A Ardanaz, Eva
%A Aune, Dagfinn
%A Boeing, Heiner
%A Dorronsoro, Miren
%A Dow, Courtney
%A Fagherazzi, Guy
%A Grioni, Sara
%A Gunter, Marc J
%A Huerta, José María
%A Ibsen, Daniel B
%A Jakobsen, Marianne Uhre
%A Kaaks, Rudolf
%A Key, Timothy J
%A Khaw, Kay-Tee
%A Kyrø, Cecilie
%A Mancini, Francesca Romana
%A Molina-Portillo, Elena
%A Murphy, Neil
%A Nilsson, Peter M
%A Onland-Moret, N Charlotte
%A Palli, Domenico
%A Panico, Salvatore
%A Poveda, Alaitz
%A Quirós, J Ramón
%A Ricceri, Fulvio
%A Sluijs, Ivonne
%A Spijkerman, Annemieke M W
%A Tjonneland, Anne
%A Tumino, Rosario
%A Winkvist, Anna
%A Langenberg, Claudia
%A Sharp, Stephen J
%A Riboli, Elio
%A Scott, Robert A
%A Forouhi, Nita G
%A Wareham, Nicholas J
%T Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.
%J Diabetologia
%V 61
%N 6
%@ 1432-0428
%C Berlin
%I Springer
%M DKFZ-2018-00579
%P 1325 - 1332
%D 2018
%X Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes.We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution.No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0-51.6
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29549418
%R 10.1007/s00125-018-4586-2
%U https://inrepo02.dkfz.de/record/132940