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000132940 0247_ $$2doi$$a10.1007/s00125-018-4586-2
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000132940 0247_ $$2ISSN$$a0012-186X
000132940 0247_ $$2ISSN$$a1432-0428
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000132940 037__ $$aDKFZ-2018-00579
000132940 041__ $$aeng
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000132940 1001_ $$aLi, Sherly X$$b0
000132940 245__ $$aInterplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.
000132940 260__ $$aBerlin$$bSpringer$$c2018
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000132940 520__ $$aGene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes.We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution.No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined.Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.
000132940 536__ $$0G:(DE-HGF)POF3-323$$a323 - Metabolic Dysfunction as Risk Factor (POF3-323)$$cPOF3-323$$fPOF III$$x0
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000132940 7001_ $$aImamura, Fumiaki$$b1
000132940 7001_ $$aSchulze, Matthias B$$b2
000132940 7001_ $$aZheng, Jusheng$$b3
000132940 7001_ $$aYe, Zheng$$b4
000132940 7001_ $$aAgudo, Antonio$$b5
000132940 7001_ $$aArdanaz, Eva$$b6
000132940 7001_ $$aAune, Dagfinn$$b7
000132940 7001_ $$aBoeing, Heiner$$b8
000132940 7001_ $$aDorronsoro, Miren$$b9
000132940 7001_ $$aDow, Courtney$$b10
000132940 7001_ $$aFagherazzi, Guy$$b11
000132940 7001_ $$aGrioni, Sara$$b12
000132940 7001_ $$aGunter, Marc J$$b13
000132940 7001_ $$aHuerta, José María$$b14
000132940 7001_ $$aIbsen, Daniel B$$b15
000132940 7001_ $$aJakobsen, Marianne Uhre$$b16
000132940 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b17$$udkfz
000132940 7001_ $$aKey, Timothy J$$b18
000132940 7001_ $$aKhaw, Kay-Tee$$b19
000132940 7001_ $$aKyrø, Cecilie$$b20
000132940 7001_ $$aMancini, Francesca Romana$$b21
000132940 7001_ $$aMolina-Portillo, Elena$$b22
000132940 7001_ $$aMurphy, Neil$$b23
000132940 7001_ $$aNilsson, Peter M$$b24
000132940 7001_ $$aOnland-Moret, N Charlotte$$b25
000132940 7001_ $$aPalli, Domenico$$b26
000132940 7001_ $$aPanico, Salvatore$$b27
000132940 7001_ $$aPoveda, Alaitz$$b28
000132940 7001_ $$aQuirós, J Ramón$$b29
000132940 7001_ $$aRicceri, Fulvio$$b30
000132940 7001_ $$aSluijs, Ivonne$$b31
000132940 7001_ $$aSpijkerman, Annemieke M W$$b32
000132940 7001_ $$aTjonneland, Anne$$b33
000132940 7001_ $$aTumino, Rosario$$b34
000132940 7001_ $$aWinkvist, Anna$$b35
000132940 7001_ $$aLangenberg, Claudia$$b36
000132940 7001_ $$aSharp, Stephen J$$b37
000132940 7001_ $$aRiboli, Elio$$b38
000132940 7001_ $$aScott, Robert A$$b39
000132940 7001_ $$aForouhi, Nita G$$b40
000132940 7001_ $$aWareham, Nicholas J$$b41
000132940 773__ $$0PERI:(DE-600)1458993-x$$a10.1007/s00125-018-4586-2$$gVol. 61, no. 6, p. 1325 - 1332$$n6$$p1325 - 1332$$tDiabetologia$$v61$$x1432-0428$$y2018
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