TY  - JOUR
AU  - Afshar-Oromieh, Ali
AU  - Sattler, Lars Peter
AU  - Steiger, Katja
AU  - Holland-Letz, Tim
AU  - da Cunha, Marcelo Livorsi
AU  - Mier, Walter
AU  - Neels, Oliver
AU  - Kopka, Klaus
AU  - Weichert, Wilko
AU  - Haberkorn, Uwe
TI  - Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT.
JO  - European journal of nuclear medicine and molecular imaging
VL  - 45
IS  - 7
SN  - 1619-7089
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DKFZ-2018-00592
SP  - 1179 - 1187
PY  - 2018
AB  - Since the introduction of 68Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN.Two patient groups with biphasic 68Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC. SUV of mediastinal/paraaortal LN of group A (n = 100) were compared to SUV of LN metastases of group B (n = 91). Additionally, 22 randomly selected mediastinal and paraaortal LN of patients without PC were immunohistochemically (IHC) analyzed for PSMA expression.In group A, 7/38 patients (18.4
LB  - PUB:(DE-HGF)16
C6  - pmid:29497802
DO  - DOI:10.1007/s00259-018-3965-8
UR  - https://inrepo02.dkfz.de/record/134799
ER  -