%0 Journal Article
%A Painter, Jodie N
%A O'Mara, Tracy A
%A Morris, Andrew P
%A Cheng, Timothy H T
%A Gorman, Maggie
%A Martin, Lynn
%A Hodson, Shirley
%A Jones, Angela
%A Martin, Nicholas G
%A Gordon, Scott
%A Henders, Anjali K
%A Attia, John
%A McEvoy, Mark
%A Holliday, Elizabeth G
%A Scott, Rodney J
%A Webb, Penelope M
%A Fasching, Peter A
%A Beckmann, Matthias W
%A Ekici, Arif B
%A Hein, Alexander
%A Rübner, Matthias
%A Hall, Per
%A Czene, Kamila
%A Dörk, Thilo
%A Dürst, Matthias
%A Hillemanns, Peter
%A Runnebaum, Ingo
%A Lambrechts, Diether
%A Amant, Frederic
%A Annibali, Daniela
%A Depreeuw, Jeroen
%A Vanderstichele, Adriaan
%A Goode, Ellen L
%A Cunningham, Julie M
%A Dowdy, Sean C
%A Winham, Stacey J
%A Trovik, Jone
%A Hoivik, Erling
%A Werner, Henrica M J
%A Krakstad, Camilla
%A Ashton, Katie
%A Otton, Geoffrey
%A Proietto, Tony
%A Tham, Emma
%A Mints, Miriam
%A Ahmed, Shahana
%A Healey, Catherine S
%A Shah, Mitul
%A Pharoah, Paul D P
%A Dunning, Alison M
%A Dennis, Joe
%A Bolla, Manjeet K
%A Michailidou, Kyriaki
%A Wang, Qin
%A Tyrer, Jonathan P
%A Hopper, John L
%A Peto, Julian
%A Swerdlow, Anthony J
%A Burwinkel, Barbara
%A Brenner, Hermann
%A Meindl, Alfons
%A Brauch, Hiltrud
%A Lindblom, Annika
%A Chang-Claude, Jenny
%A Couch, Fergus J
%A Giles, Graham G
%A Kristensen, Vessela N
%A Cox, Angela
%A Zondervan, Krina T
%A Nyholt, Dale R
%A MacGregor, Stuart
%A Montgomery, Grant W
%A Tomlinson, Ian
%A Easton, Douglas F
%A Thompson, Deborah J
%A Spurdle, Amanda B
%T Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.
%J Cancer medicine
%V 7
%N 5
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2018-00603
%P 1978 - 1987
%D 2018
%X Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg  = 0.23, P = 9.3 × 10-3 ), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10-3 ) and concordance in effect direction (P = 2.0 × 10-3 ) between the two diseases. Cross-disease GWAS meta-analysis highlighted 13 distinct loci associated at P ≤ 10-5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10-8 , OR = 1.11, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29608257
%2 pmc:PMC5943470
%R 10.1002/cam4.1445
%U https://inrepo02.dkfz.de/record/134812