TY  - JOUR
AU  - Zimmer, Philipp
AU  - Baumann, Freerk T
AU  - Oberste, Max
AU  - Schmitt, Joachim
AU  - Joisten, Niklas
AU  - Hartig, Philipp
AU  - Schenk, Alexander
AU  - Kuhn, Rafaela
AU  - Bloch, Wilhelm
AU  - Reuss-Borst, Monika
TI  - Influence of Personalized Exercise Recommendations During Rehabilitation on the Sustainability of Objectively Measured Physical Activity Levels, Fatigue, and Fatigue-Related Biomarkers in Patients With Breast Cancer.
JO  - Integrative cancer therapies
VL  - 17
IS  - 2
SN  - 1552-695X
CY  - Thousand Oaks, Calif.
PB  - Sage
M1  - DKFZ-2018-00604
SP  - 306 - 311
PY  - 2018
AB  - Only one-third of patients with breast cancer reach the recommended activity level of 15 to 25 MET h/wk. The aim of this study was to determine the influence of personalized exercise recommendations during rehabilitation on patients' physical activity level, fatigue, and self-perceived cognitive function as well as on side effect-associated biomarkers.Total metabolic rate, physical activity level, mean MET and steps, fatigue, self-perceived cognitive functioning , and biomarkers (C-reactive protein [CRP], interleukin 6, macrophage migration inhibiting factor [MIF], tumor necrosis factor [TNF]-α, brain-derived neurotrophic factor [BDNF], insulin-like growth factor 1 [IGF1]) were assessed in 60 patients with breast cancer in the aftercare phase before ( t0) and 8 months after ( t1) the intervention. The rehabilitation program consisted of an initial 3-week period and a 1-week stay after 4 months.Paired t-test indicated a statistically significant increase in all activity outcomes from t0 to t1. Patients' mean activity level significantly increased from 14.89 to 17.88 MET h/wk. Fatigue and self-perceived cognitive functioning significantly improved from t0 to t1. CRP levels significantly decreased, and BDNF as well as IGF1 levels significantly increased over time. Correlation analysis revealed statistically significant negative associations between fatigue, physical activity, and markers of inflammation (TNF-α and MIF). Furthermore, significant positive correlations between subjective cognitive functioning and all dimensions of fatigue were observed.The results support the importance of personalized exercise recommendations to increase physical activity levels in patients with breast cancer. Furthermore, the results highlighti an association between physical activity, fatigue, and inflammation.
LB  - PUB:(DE-HGF)16
C6  - pmid:28617135
DO  - DOI:10.1177/1534735417713301
UR  - https://inrepo02.dkfz.de/record/134813
ER  -