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@ARTICLE{Zimmer:134813,
      author       = {P. Zimmer$^*$ and F. T. Baumann and M. Oberste and J.
                      Schmitt and N. Joisten and P. Hartig and A. Schenk and R.
                      Kuhn and W. Bloch and M. Reuss-Borst},
      title        = {{I}nfluence of {P}ersonalized {E}xercise {R}ecommendations
                      {D}uring {R}ehabilitation on the {S}ustainability of
                      {O}bjectively {M}easured {P}hysical {A}ctivity {L}evels,
                      {F}atigue, and {F}atigue-{R}elated {B}iomarkers in
                      {P}atients {W}ith {B}reast {C}ancer.},
      journal      = {Integrative cancer therapies},
      volume       = {17},
      number       = {2},
      issn         = {1552-695X},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage},
      reportid     = {DKFZ-2018-00604},
      pages        = {306 - 311},
      year         = {2018},
      abstract     = {Only one-third of patients with breast cancer reach the
                      recommended activity level of 15 to 25 MET h/wk. The aim of
                      this study was to determine the influence of personalized
                      exercise recommendations during rehabilitation on patients'
                      physical activity level, fatigue, and self-perceived
                      cognitive function as well as on side effect-associated
                      biomarkers.Total metabolic rate, physical activity level,
                      mean MET and steps, fatigue, self-perceived cognitive
                      functioning , and biomarkers (C-reactive protein [CRP],
                      interleukin 6, macrophage migration inhibiting factor [MIF],
                      tumor necrosis factor [TNF]-α, brain-derived neurotrophic
                      factor [BDNF], insulin-like growth factor 1 [IGF1]) were
                      assessed in 60 patients with breast cancer in the aftercare
                      phase before ( t0) and 8 months after ( t1) the
                      intervention. The rehabilitation program consisted of an
                      initial 3-week period and a 1-week stay after 4
                      months.Paired t-test indicated a statistically significant
                      increase in all activity outcomes from t0 to t1. Patients'
                      mean activity level significantly increased from 14.89 to
                      17.88 MET h/wk. Fatigue and self-perceived cognitive
                      functioning significantly improved from t0 to t1. CRP levels
                      significantly decreased, and BDNF as well as IGF1 levels
                      significantly increased over time. Correlation analysis
                      revealed statistically significant negative associations
                      between fatigue, physical activity, and markers of
                      inflammation (TNF-α and MIF). Furthermore, significant
                      positive correlations between subjective cognitive
                      functioning and all dimensions of fatigue were observed.The
                      results support the importance of personalized exercise
                      recommendations to increase physical activity levels in
                      patients with breast cancer. Furthermore, the results
                      highlighti an association between physical activity,
                      fatigue, and inflammation.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28617135},
      doi          = {10.1177/1534735417713301},
      url          = {https://inrepo02.dkfz.de/record/134813},
}