%0 Journal Article
%A Brück, Katharina
%A Jager, Kitty J
%A Zoccali, Carmine
%A Bello, Aminu K
%A Minutolo, Roberto
%A Ioannou, Kyriakos
%A Verbeke, Francis
%A Völzke, Henry
%A Arnlöv, Johan
%A Leonardis, Daniela
%A Ferraro, Pietro Manuel
%A Brenner, Hermann
%A Caplin, Ben
%A Kalra, Philip A
%A Wanner, Christoph
%A Castelao, Alberto Martinez
%A Gorriz, Jose Luis
%A Hallan, Stein
%A Rothenbacher, Dietrich
%A Gibertoni, Dino
%A De Nicola, Luca
%A Heinze, Georg
%A Van Biesen, Wim
%A Stel, Vianda S
%T Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe.
%J Kidney international
%V 93
%N 6
%@ 0085-2538
%C Basingstoke
%I Nature Publishing Group
%M DKFZ-2018-00611
%P 1432 - 1441
%D 2018
%X The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR. Results were adjusted for important risk factors (baseline eGFR, age, sex, albuminuria, primary renal disease, diabetes, hypertension, obesity and smoking) in 27,771 patients from five countries. The adjusted mean annual eGFR decline varied from 0.77 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29656901
%R 10.1016/j.kint.2018.01.008
%U https://inrepo02.dkfz.de/record/134821