TY  - JOUR
AU  - Brück, Katharina
AU  - Jager, Kitty J
AU  - Zoccali, Carmine
AU  - Bello, Aminu K
AU  - Minutolo, Roberto
AU  - Ioannou, Kyriakos
AU  - Verbeke, Francis
AU  - Völzke, Henry
AU  - Arnlöv, Johan
AU  - Leonardis, Daniela
AU  - Ferraro, Pietro Manuel
AU  - Brenner, Hermann
AU  - Caplin, Ben
AU  - Kalra, Philip A
AU  - Wanner, Christoph
AU  - Castelao, Alberto Martinez
AU  - Gorriz, Jose Luis
AU  - Hallan, Stein
AU  - Rothenbacher, Dietrich
AU  - Gibertoni, Dino
AU  - De Nicola, Luca
AU  - Heinze, Georg
AU  - Van Biesen, Wim
AU  - Stel, Vianda S
TI  - Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe.
JO  - Kidney international
VL  - 93
IS  - 6
SN  - 0085-2538
CY  - Basingstoke
PB  - Nature Publishing Group
M1  - DKFZ-2018-00611
SP  - 1432 - 1441
PY  - 2018
AB  - The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR. Results were adjusted for important risk factors (baseline eGFR, age, sex, albuminuria, primary renal disease, diabetes, hypertension, obesity and smoking) in 27,771 patients from five countries. The adjusted mean annual eGFR decline varied from 0.77 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29656901
DO  - DOI:10.1016/j.kint.2018.01.008
UR  - https://inrepo02.dkfz.de/record/134821
ER  -