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@ARTICLE{Brck:134821,
      author       = {K. Brück and K. J. Jager and C. Zoccali and A. K. Bello
                      and R. Minutolo and K. Ioannou and F. Verbeke and H. Völzke
                      and J. Arnlöv and D. Leonardis and P. M. Ferraro and H.
                      Brenner$^*$ and B. Caplin and P. A. Kalra and C. Wanner and
                      A. M. Castelao and J. L. Gorriz and S. Hallan and D.
                      Rothenbacher and D. Gibertoni and L. De Nicola and G. Heinze
                      and W. Van Biesen and V. S. Stel},
      collaboration = {E. C. B. Consortium},
      title        = {{D}ifferent rates of progression and mortality in patients
                      with chronic kidney disease at outpatient nephrology clinics
                      across {E}urope.},
      journal      = {Kidney international},
      volume       = {93},
      number       = {6},
      issn         = {0085-2538},
      address      = {Basingstoke},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2018-00611},
      pages        = {1432 - 1441},
      year         = {2018},
      abstract     = {The incidence of renal replacement therapy varies across
                      countries. However, little is known about the epidemiology
                      of chronic kidney disease (CKD) outcomes. Here we describe
                      progression and mortality risk of patients with CKD but not
                      on renal replacement therapy at outpatient nephrology
                      clinics across Europe using individual data from nine CKD
                      cohorts participating in the European CKD Burden Consortium.
                      A joint model assessed the mean change in estimated
                      glomerular filtration rate (eGFR) and mortality risk
                      simultaneously, thereby accounting for mortality risk when
                      estimating eGFR decline and vice versa, while also
                      correcting for the measurement error in eGFR. Results were
                      adjusted for important risk factors (baseline eGFR, age,
                      sex, albuminuria, primary renal disease, diabetes,
                      hypertension, obesity and smoking) in 27,771 patients from
                      five countries. The adjusted mean annual eGFR decline varied
                      from 0.77 $(95\%$ confidence interval 0.45, 1.08)
                      ml/min/1.73m2 in the Belgium cohort to 2.43 (2.11, 2.75)
                      ml/min/1.73m2 in the Spanish cohort. As compared to the
                      Italian PIRP cohort, the adjusted mortality hazard ratio
                      varied from 0.22 (0.11, 0.43) in the London LACKABO cohort
                      to 1.30 (1.13, 1.49) in the English CRISIS cohort. These
                      results suggest that the eGFR decline showed minor variation
                      but mortality showed the most variation. Thus, different
                      health care organization systems are potentially associated
                      with differences in outcome of patients with CKD within
                      Europe. These results can be used by policy makers to plan
                      resources on a regional, national and European level.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29656901},
      doi          = {10.1016/j.kint.2018.01.008},
      url          = {https://inrepo02.dkfz.de/record/134821},
}