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@ARTICLE{Mackay:134833,
author = {A. Mackay and A. Burford and V. Molinari and D. Jones$^*$
and E. Izquierdo and J. Brouwer-Visser and F. Giangaspero
and C. Haberler and T. Pietsch and T. S. Jacques and D.
Figarella-Branger and D. Rodriguez and P. S. Morgan and P.
Raman and A. J. Waanders and A. C. Resnick and M. Massimino
and M. L. Garrè and H. Smith and D. Capper$^*$ and S.
Pfister$^*$ and T. Würdinger and R. Tam and J. Garcia and
M. D. Thakur and G. Vassal and J. Grill and T. Jaspan and P.
Varlet and C. Jones},
title = {{M}olecular, {P}athological, {R}adiological, and {I}mmune
{P}rofiling of {N}on-brainstem {P}ediatric {H}igh-{G}rade
{G}lioma from the {HERBY} {P}hase {II} {R}andomized
{T}rial.},
journal = {Cancer cell},
volume = {33},
number = {5},
issn = {1535-6108},
address = {Cambridge, Mass.},
publisher = {Cell Press},
reportid = {DKFZ-2018-00623},
pages = {829 - 842.e5},
year = {2018},
abstract = {The HERBY trial was a phase II open-label, randomized,
multicenter trial evaluating bevacizumab (BEV) in addition
to temozolomide/radiotherapy in patients with newly
diagnosed non-brainstem high-grade glioma (HGG) between the
ages of 3 and 18 years. We carried out comprehensive
molecular analysis integrated with pathology, radiology, and
immune profiling. In post-hoc subgroup analysis,
hypermutator tumors (mismatch repair deficiency and somatic
POLE/POLD1 mutations) and those biologically resembling
pleomorphic xanthoastrocytoma ([PXA]-like, driven by
$BRAF_V600E$ or NF1 mutation) had significantly more CD8+
tumor-infiltrating lymphocytes, and longer survival with the
addition of BEV. Histone H3 subgroups (hemispheric G34R/V
and midline K27M) had a worse outcome and were immune cold.
Future clinical trials will need to take into account the
diversity represented by the term 'HGG' in the pediatric
population.},
cin = {B062 / L101 / G380 / L201},
ddc = {610},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331 /
I:(DE-He78)G380-20160331 / I:(DE-He78)L201-20160331},
pnm = {319H - Addenda (POF3-319H)},
pid = {G:(DE-HGF)POF3-319H},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29763623},
pmc = {pmc:PMC5956280},
doi = {10.1016/j.ccell.2018.04.004},
url = {https://inrepo02.dkfz.de/record/134833},
}