guest ::
| Home > Publications database > Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. > print |
| Home > Publications database > Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. > print |
| 001 | 134833 | ||
| 005 | 20240229105043.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2018.04.004 |2 doi |
| 024 | 7 | _ | |a pmid:29763623 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5956280 |2 pmc |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:41388262 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-00623 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Mackay, Alan |b 0 |
| 245 | _ | _ | |a Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2018 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1660038281_23715 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE/POLD1 mutations) and those biologically resembling pleomorphic xanthoastrocytoma ([PXA]-like, driven by BRAF_V600E or NF1 mutation) had significantly more CD8+ tumor-infiltrating lymphocytes, and longer survival with the addition of BEV. Histone H3 subgroups (hemispheric G34R/V and midline K27M) had a worse outcome and were immune cold. Future clinical trials will need to take into account the diversity represented by the term 'HGG' in the pediatric population. |
| 536 | _ | _ | |a 319H - Addenda (POF3-319H) |0 G:(DE-HGF)POF3-319H |c POF3-319H |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Burford, Anna |b 1 |
| 700 | 1 | _ | |a Molinari, Valeria |b 2 |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 3 |u dkfz |
| 700 | 1 | _ | |a Izquierdo, Elisa |b 4 |
| 700 | 1 | _ | |a Brouwer-Visser, Jurriaan |b 5 |
| 700 | 1 | _ | |a Giangaspero, Felice |b 6 |
| 700 | 1 | _ | |a Haberler, Christine |b 7 |
| 700 | 1 | _ | |a Pietsch, Torsten |b 8 |
| 700 | 1 | _ | |a Jacques, Thomas S |b 9 |
| 700 | 1 | _ | |a Figarella-Branger, Dominique |b 10 |
| 700 | 1 | _ | |a Rodriguez, Daniel |b 11 |
| 700 | 1 | _ | |a Morgan, Paul S |b 12 |
| 700 | 1 | _ | |a Raman, Pichai |b 13 |
| 700 | 1 | _ | |a Waanders, Angela J |b 14 |
| 700 | 1 | _ | |a Resnick, Adam C |b 15 |
| 700 | 1 | _ | |a Massimino, Maura |b 16 |
| 700 | 1 | _ | |a Garrè, Maria Luisa |b 17 |
| 700 | 1 | _ | |a Smith, Helen |b 18 |
| 700 | 1 | _ | |a Capper, David |0 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |b 19 |u dkfz |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 20 |u dkfz |
| 700 | 1 | _ | |a Würdinger, Thomas |b 21 |
| 700 | 1 | _ | |a Tam, Rachel |b 22 |
| 700 | 1 | _ | |a Garcia, Josep |b 23 |
| 700 | 1 | _ | |a Thakur, Meghna Das |b 24 |
| 700 | 1 | _ | |a Vassal, Gilles |b 25 |
| 700 | 1 | _ | |a Grill, Jacques |b 26 |
| 700 | 1 | _ | |a Jaspan, Tim |b 27 |
| 700 | 1 | _ | |a Varlet, Pascale |b 28 |
| 700 | 1 | _ | |a Jones, Chris |b 29 |
| 773 | _ | _ | |a 10.1016/j.ccell.2018.04.004 |g Vol. 33, no. 5, p. 829 - 842.e5 |0 PERI:(DE-600)2074034-7 |n 5 |p 829 - 842.e5 |t Cancer cell |v 33 |y 2018 |x 1535-6108 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:134833 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 19 |6 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 20 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-319H |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Addenda |x 0 |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CANCER CELL : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 20 |0 StatID:(DE-HGF)9920 |2 StatID |b CANCER CELL : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)L201-20160331 |k L201 |l DKTK Berlin |x 3 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L201-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|