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@ARTICLE{Wunram:134844,
      author       = {H. L. Wunram and S. Hamacher and M. Hellmich and M. Volk
                      and F. Jänicke and F. Reinhard and W. Bloch and P.
                      Zimmer$^*$ and C. Graf and E. Schönau and G. Lehmkuhl and
                      S. Bender and O. Fricke},
      title        = {{W}hole body vibration added to treatment as usual is
                      effective in adolescents with depression: a partly
                      randomized, three-armed clinical trial in inpatients.},
      journal      = {European child $\&$ adolescent psychiatry},
      volume       = {27},
      number       = {5},
      issn         = {1018-8827},
      address      = {Darmstadt},
      publisher    = {Steinkopff},
      reportid     = {DKFZ-2018-00634},
      pages        = {645 - 662},
      year         = {2018},
      abstract     = {There is growing evidence for the effectiveness of exercise
                      in the treatment of adult major depression. With regard to
                      adolescents, clinical trials are scarce. Due to the inherent
                      symptoms of depression (lack of energy, low motivation to
                      exercise), endurance training forms could be too demanding
                      especially in the first weeks of treatment. We hypothesized
                      that an easy-to-perform passive muscular training on a whole
                      body vibration (WBV) device has equal anti-depressive
                      effects compared to a cardiovascular training, both
                      administered as add-ons to treatment as usual (TAU).
                      Secondly, we presumed that both exercise interventions would
                      be superior in their response, compared to TAU. In 2 years
                      64 medication-naïve depressed inpatients aged 13-18, were
                      included. Both exercise groups fulfilled a supervised
                      vigorous training for 6 weeks. Depressive symptoms were
                      assessed by self-report ('Depressions Inventar für Kinder
                      und Jugendliche'-DIKJ) before intervention and after weeks
                      6, 14 and 26. Compared to TAU, both groups responded earlier
                      and more strongly measured by DIKJ scores, showing a trend
                      for the WBV group after week 6 (p = 0.082). The decrease
                      became statistically significant for both intervention
                      groups after week 26 (p = 0.037 for ergometer and
                      p = 0.042 for WBV). Remission rates amounted to $39.7\%$
                      after week 6 and $66\%$ after week 26, compared to $25\%$
                      after week 26 in TAU. These results provide qualified
                      support for the effectiveness of exercise as add-on
                      treatment for medication-naïve depressed adolescents. The
                      present results are limited by the not randomized control
                      group.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29119301},
      doi          = {10.1007/s00787-017-1071-2},
      url          = {https://inrepo02.dkfz.de/record/134844},
}