TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Weigl, Korbinian
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Flexible sigmoidoscopy in colorectal cancer screening: implications of different colonoscopy referral strategies.
JO  - European journal of epidemiology
VL  - 33
IS  - 5
SN  - 1573-7284
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2018-00652
SP  - 473 - 484
PY  - 2018
AB  - Flexible sigmoidoscopy (FS) screening reduces colorectal cancer incidence and mortality. Its potential to detect proximal neoplasms depends on colonoscopy referral. We estimated diagnostic performance of sigmoidoscopy using 12 different referral criteria in detecting colorectal cancer and advanced adenomas. Colonoscopy results from 14,947 participants of screening colonoscopy in Germany were used to derive sensitivity of sigmoidoscopy for colorectal cancer, advanced adenomas (AAs), and any advanced neoplasms in the proximal colon. It was assumed that FS detects the same neoplasms as colonoscopy within its reach and that distal neoplasms would be followed by colonoscopy. In addition, numbers of colonoscopies needed (NCN) to detect one proximal advanced neoplasm were calculated. The most advanced findings during colonoscopy were colorectal cancer in 213 subjects (1.4
LB  - PUB:(DE-HGF)16
C6  - pmid:29752577
C2  - pmc:PMC5968045
DO  - DOI:10.1007/s10654-018-0404-x
UR  - https://inrepo02.dkfz.de/record/134862
ER  -