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@ARTICLE{Bizjak:134877,
      author       = {D. A. Bizjak and D. Jacko and P. Zimmer$^*$ and S. Gehlert
                      and W. Bloch and M. Grau},
      title        = {{A}cute alterations in the hematological and
                      hemorheological profile induced by resistance training and
                      possible implication for microvascular functionality.},
      journal      = {Microvascular research},
      volume       = {118},
      issn         = {0026-2862},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2018-00665},
      pages        = {137 - 143},
      year         = {2018},
      abstract     = {Depending on the exercise variables and training design,
                      resistance exercise can be applied to gain muscle mass,
                      prevent diseases like osteoporosis and sarcopenia or
                      generally increase strength capacity. But the influence on
                      blood flow parameters and possible consequences in health
                      and disease are less understood. To examine the possible
                      impact of resistance exercise of different duration on
                      hemorheology, oxidative stress and microvascular function,
                      participants (n = 6) performed lower-limb resistance
                      exercise of the quadriceps femoris. Loading consisted of 1
                      (S1), 5 (S5) and 10 (S10) sets, on separated days, at the
                      individual 10 repetition maximum. Blood samples were taken
                      before (Pre) and after (Post0) each set as well after a
                      25-min recovery period (Post25). Hemograms were measured to
                      analyze hematocrit, white blood cell (WBC) count and red
                      blood cell (RBC) count. RBC deformability and aggregation
                      were measured by ektacytometry and syllectometry to
                      determine hemorheological responses. Plasma and RBC nitrate
                      were measured by chemiluminescence detection to determine
                      nitric oxide production. Formation of N-tyrosine and plasma
                      malondialdehyde to determine oxidative stress and lipid
                      peroxidation were measured by immunostaining and ELISA,
                      respectively. Hematocrit, RBC, WBC count and aggregation
                      increased Post0 in each protocol with subsequently decreased
                      values Post25 below Pre values. High effect size was
                      observed regarding deformability during the different sets.
                      RBC nitrite analysis revealed effect size alterations
                      between the trainings, whereas plasma nitrite was not
                      affected. Effects size was evident in lipid peroxidation,
                      whereas N-tyrosine concentration was not altered. Lower-limb
                      resistance exercise induced acute changes in hematological
                      and hemorheological parameters, whereby intermittent
                      hemodilution and plasma shifts seemed the major contributor.
                      The acute adaptations of RBC function seen during short
                      duration resistance exercise might contribute to beneficial
                      effects on microvascular circulation with a low oxidative
                      stress response.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29559378},
      doi          = {10.1016/j.mvr.2018.03.007},
      url          = {https://inrepo02.dkfz.de/record/134877},
}