TY  - JOUR
AU  - Nattenmüller, Cina Joseph
AU  - Kriegsmann, Mark
AU  - Sookthai, Disorn
AU  - Turzanski-Fortner, Renée
AU  - Steffen, Annika
AU  - Walter, Britta
AU  - Johnson, Theron Scot
AU  - Kneisel, Jutta
AU  - Katzke, Verena
AU  - Bergmann, Manuela
AU  - Sinn, Hans Peter
AU  - Schirmacher, Peter
AU  - Herpel, Esther
AU  - Boeing, Heiner
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study.
JO  - BMC cancer
VL  - 18
IS  - 1
SN  - 1471-2407
CY  - London
PB  - BioMed Central
M1  - DKFZ-2018-00678
SP  - 616
PY  - 2018
AB  - Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype. Here, we evaluated whether obesity is differentially associated with the risk of breast tumor subtypes, as defined by 6 immunohistochemical markers (ER, PR, HER2, Ki67, Bcl-2 and p53, separately and combined), in the prospective EPIC-Germany Study (n = 27,012).Formalin-fixed and paraffin-embedded (FFPE) tumor tissues of 657 incident breast cancer cases were used for histopathological analyses. Associations between BMI and breast cancer risk across subtypes were evaluated by multivariable Cox regression models stratified by menopausal status and hormone therapy (HT) use.Among postmenopausal non-users of HT, higher BMI was significantly associated with an increased risk of less aggressive, i.e. ER+, PR+, HER2-, Ki67low, Bcl-2+ and p53- tumors (HR per 5 kg/m2: 1.44 [1.10, 1.90], p = 0.009), but not with risk of more aggressive tumor subtypes. Among postmenopausal users of HT, BMI was significantly inversely associated with less aggressive tumors (HR per 5 kg/m2: 0.68 [0.50, 0.94], p = 0.018). Finally, among pre- and perimenopausal women, Cox regression models did not reveal significant linear associations between BMI and risk of any tumor subtype, although analyses by BMI tertiles showed a significantly lower risk of less aggressive tumors for women in the highest tertile (HR: 0.55 [0.33, 0.93]).Overall, our results suggest that obesity is related to risk of breast tumors with lower aggressiveness, a finding that requires replication in larger-scale analyses of pooled prospective data.
LB  - PUB:(DE-HGF)16
C6  - pmid:29855282
C2  - pmc:PMC5984403
DO  - DOI:10.1186/s12885-018-4548-6
UR  - https://inrepo02.dkfz.de/record/134890
ER  -