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@ARTICLE{Ricci:135967,
author = {C. Ricci and A. Wood and D. Muller and M. J. Gunter and A.
Agudo and H. Boeing and Y. T. van der Schouw and S.
Warnakula and C. Saieva and A. Spijkerman and I. Sluijs and
A. Tjønneland and C. Kyrø and E. Weiderpass and T.
Kühn$^*$ and R. Kaaks$^*$ and M.-J. Sánchez and S. Panico
and C. Agnoli and D. Palli and R. Tumino and G. Engström
and O. Melander and F. Bonnet and J. M. A. Boer and T. J.
Key and R. C. Travis and K. Overvad and W. M. M. Verschuren
and J. R. Quirós and A. Trichopoulou and E.-M. Papatesta
and E. Peppa and C. M. Iribas and D. Gavrila and A.-S.
Forslund and J.-H. Jansson and G. Matullo and L. Arriola and
H. Freisling and C. Lassale and I. Tzoulaki and S. J. Sharp
and N. G. Forouhi and C. Langenberg and R. Saracci and M.
Sweeting and P. Brennan and A. S. Butterworth and E. Riboli
and N. J. Wareham and J. Danesh and P. Ferrari},
title = {{A}lcohol intake in relation to non-fatal and fatal
coronary heart disease and stroke: {EPIC}-{CVD} case-cohort
study.},
journal = {The BMJ},
volume = {361},
issn = {0140-6736},
address = {London},
publisher = {British Medical Association56099},
reportid = {DKFZ-2018-00704},
pages = {k934},
year = {2018},
abstract = {To investigate the association between alcohol consumption
(at baseline and over lifetime) and non-fatal and fatal
coronary heart disease (CHD) and stroke.Multicentre
case-cohort study.A study of cardiovascular disease (CVD)
determinants within the European Prospective Investigation
into Cancer and nutrition cohort (EPIC-CVD) from eight
European countries.32 549 participants without baseline
CVD, comprised of incident CVD cases and a subcohort for
comparison.Non-fatal and fatal CHD and stroke (including
ischaemic and haemorrhagic stroke).There were 9307 non-fatal
CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733
fatal stroke. Baseline alcohol intake was inversely
associated with non-fatal CHD, with a hazard ratio of 0.94
$(95\%$ confidence interval 0.92 to 0.96) per 12 g/day
higher intake. There was a J shaped association between
baseline alcohol intake and risk of fatal CHD. The hazard
ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and
0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9
g/day, and 30.0-59.9 g/day of total alcohol intake,
respectively, compared with 0.1-4.9 g/day. In contrast,
hazard ratios for non-fatal and fatal stroke risk were 1.04
(1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day
increase in baseline alcohol intake, respectively, including
broadly similar findings for ischaemic and haemorrhagic
stroke. Associations with cardiovascular outcomes were
broadly similar with average lifetime alcohol consumption as
for baseline alcohol intake, and across the eight countries
studied. There was no strong evidence for interactions of
alcohol consumption with smoking status on the risk of CVD
events.Alcohol intake was inversely associated with
non-fatal CHD risk but positively associated with the risk
of different stroke subtypes. This highlights the opposing
associations of alcohol intake with different CVD types and
strengthens the evidence for policies to reduce alcohol
consumption.},
keywords = {Urea (NLM Chemicals)},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
pid = {G:(DE-HGF)POF3-323},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:88564},
url = {https://inrepo02.dkfz.de/record/135967},
}