% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ricci:135967,
      author       = {C. Ricci and A. Wood and D. Muller and M. J. Gunter and A.
                      Agudo and H. Boeing and Y. T. van der Schouw and S.
                      Warnakula and C. Saieva and A. Spijkerman and I. Sluijs and
                      A. Tjønneland and C. Kyrø and E. Weiderpass and T.
                      Kühn$^*$ and R. Kaaks$^*$ and M.-J. Sánchez and S. Panico
                      and C. Agnoli and D. Palli and R. Tumino and G. Engström
                      and O. Melander and F. Bonnet and J. M. A. Boer and T. J.
                      Key and R. C. Travis and K. Overvad and W. M. M. Verschuren
                      and J. R. Quirós and A. Trichopoulou and E.-M. Papatesta
                      and E. Peppa and C. M. Iribas and D. Gavrila and A.-S.
                      Forslund and J.-H. Jansson and G. Matullo and L. Arriola and
                      H. Freisling and C. Lassale and I. Tzoulaki and S. J. Sharp
                      and N. G. Forouhi and C. Langenberg and R. Saracci and M.
                      Sweeting and P. Brennan and A. S. Butterworth and E. Riboli
                      and N. J. Wareham and J. Danesh and P. Ferrari},
      title        = {{A}lcohol intake in relation to non-fatal and fatal
                      coronary heart disease and stroke: {EPIC}-{CVD} case-cohort
                      study.},
      journal      = {The BMJ},
      volume       = {361},
      issn         = {0140-6736},
      address      = {London},
      publisher    = {British Medical Association56099},
      reportid     = {DKFZ-2018-00704},
      pages        = {k934},
      year         = {2018},
      abstract     = {To investigate the association between alcohol consumption
                      (at baseline and over lifetime) and non-fatal and fatal
                      coronary heart disease (CHD) and stroke.Multicentre
                      case-cohort study.A study of cardiovascular disease (CVD)
                      determinants within the European Prospective Investigation
                      into Cancer and nutrition cohort (EPIC-CVD) from eight
                      European countries.32 549 participants without baseline
                      CVD, comprised of incident CVD cases and a subcohort for
                      comparison.Non-fatal and fatal CHD and stroke (including
                      ischaemic and haemorrhagic stroke).There were 9307 non-fatal
                      CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733
                      fatal stroke. Baseline alcohol intake was inversely
                      associated with non-fatal CHD, with a hazard ratio of 0.94
                      $(95\%$ confidence interval 0.92 to 0.96) per 12 g/day
                      higher intake. There was a J shaped association between
                      baseline alcohol intake and risk of fatal CHD. The hazard
                      ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and
                      0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9
                      g/day, and 30.0-59.9 g/day of total alcohol intake,
                      respectively, compared with 0.1-4.9 g/day. In contrast,
                      hazard ratios for non-fatal and fatal stroke risk were 1.04
                      (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day
                      increase in baseline alcohol intake, respectively, including
                      broadly similar findings for ischaemic and haemorrhagic
                      stroke. Associations with cardiovascular outcomes were
                      broadly similar with average lifetime alcohol consumption as
                      for baseline alcohol intake, and across the eight countries
                      studied. There was no strong evidence for interactions of
                      alcohol consumption with smoking status on the risk of CVD
                      events.Alcohol intake was inversely associated with
                      non-fatal CHD risk but positively associated with the risk
                      of different stroke subtypes. This highlights the opposing
                      associations of alcohol intake with different CVD types and
                      strengthens the evidence for policies to reduce alcohol
                      consumption.},
      keywords     = {Urea (NLM Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:88564},
      url          = {https://inrepo02.dkfz.de/record/135967},
}