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000135970 0247_ $$2ISSN$$a1661-6596
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000135970 037__ $$aDKFZ-2018-00706
000135970 041__ $$aeng
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000135970 1001_ $$aRong, Chao$$b0
000135970 245__ $$aEstrogen Receptor Signaling in Radiotherapy: From Molecular Mechanisms to Clinical Studies.
000135970 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2018
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000135970 520__ $$aNumerous studies have established a proof of concept that abnormal expression and function of estrogen receptors (ER) are crucial processes in initiation and development of hormone-related cancers and also affect the efficacy of anti-cancer therapy. Radiotherapy has been applied as one of the most common and potent therapeutic strategies, which is synergistic with surgical excision, chemotherapy and targeted therapy for treating malignant tumors. However, the impact of ionizing radiation on ER expression and ER-related signaling in cancer tissue, as well as the interaction between endocrine and irradiation therapy remains largely elusive. This review will discuss recent findings on ER and ER-related signaling, which are relevant for cancer radiotherapy. In addition, we will summarize pre-clinical and clinical studies that evaluate the consequences of anti-estrogen and irradiation therapy in cancer, including emerging studies on head and neck cancer, which might improve the understanding and development of novel therapeutic strategies for estrogen-related cancers.
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000135970 7001_ $$0P:(DE-HGF)0$$aMeinert, Étienne Fasolt Richard Corvin$$b1
000135970 7001_ $$0P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f$$aHess, Jochen$$b2$$eLast author$$udkfz
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