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@ARTICLE{Rong:135970,
      author       = {C. Rong and É. F. R. C. Meinert$^*$ and J. Hess$^*$},
      title        = {{E}strogen {R}eceptor {S}ignaling in {R}adiotherapy: {F}rom
                      {M}olecular {M}echanisms to {C}linical {S}tudies.},
      journal      = {International journal of molecular sciences},
      volume       = {19},
      number       = {3},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2018-00706},
      pages        = {713 -},
      year         = {2018},
      abstract     = {Numerous studies have established a proof of concept that
                      abnormal expression and function of estrogen receptors (ER)
                      are crucial processes in initiation and development of
                      hormone-related cancers and also affect the efficacy of
                      anti-cancer therapy. Radiotherapy has been applied as one of
                      the most common and potent therapeutic strategies, which is
                      synergistic with surgical excision, chemotherapy and
                      targeted therapy for treating malignant tumors. However, the
                      impact of ionizing radiation on ER expression and ER-related
                      signaling in cancer tissue, as well as the interaction
                      between endocrine and irradiation therapy remains largely
                      elusive. This review will discuss recent findings on ER and
                      ER-related signaling, which are relevant for cancer
                      radiotherapy. In addition, we will summarize pre-clinical
                      and clinical studies that evaluate the consequences of
                      anti-estrogen and irradiation therapy in cancer, including
                      emerging studies on head and neck cancer, which might
                      improve the understanding and development of novel
                      therapeutic strategies for estrogen-related cancers.},
      subtyp        = {Review Article},
      cin          = {E221 / G405},
      ddc          = {570},
      cid          = {I:(DE-He78)E221-20160331 / I:(DE-He78)G405-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29498642},
      pmc          = {pmc:PMC5877574},
      doi          = {10.3390/ijms19030713},
      url          = {https://inrepo02.dkfz.de/record/135970},
}