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@ARTICLE{Bauer:136016,
      author       = {C. Bauer$^*$ and A. A. Abdul Pari$^*$ and V. Umansky$^*$
                      and J. Utikal$^*$ and P. Boukamp$^*$ and H. Augustin$^*$ and
                      S. Goerdt and C. Géraud and M. Felcht$^*$},
      title        = {{T}-lymphocyte profiles differ between keratoacanthomas and
                      invasive squamous cell carcinomas of the human skin.},
      journal      = {Cancer immunology immunotherapy},
      volume       = {67},
      number       = {7},
      issn         = {1432-0851},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-00716},
      pages        = {1147 - 1157},
      year         = {2018},
      note         = {DKFZ-ZMBH-Allianz},
      abstract     = {T-lymphocytes are involved in tumor progression and
                      regression. Actinic keratoses (AK) are atypical
                      proliferations of keratinocytes of the skin. Some AK
                      progress into invasive cutaneous squamous cell carcinomas
                      (cSCC). Keratoacanthomas (KA) are either classified as a
                      cSCC subtype or a benign tumor with histologic resemblance
                      to well-differentiated cSCC as it is supposed to regress
                      spontaneously. In contrast, cSCC represent malignant tumors
                      that may metastasize.To compare the T-lymphocyte profiles of
                      AK, KA and cSCC in relation to PD-L1 expression.Tissue
                      micro-arrays of 103 cases of AK, 43 cases of KA and 106
                      cases of cSCC were stained by immunohistochemistry for
                      E-cadherin, CD3, CD4, CD8, FOXp3, and the receptor-ligand
                      pair PD-1/PD-L1. Immunohistological scores were
                      computationally determined to assess PD-L1 expression as
                      well as the expression profiles of T-lymphocytes.AK had
                      lower numbers of CD3+ and PD-1+ cells compared to KA and
                      lower numbers of CD3+, CD8+ and PD-1+ cells in comparison
                      with cSCC. KA showed significantly higher numbers of CD4+
                      and FOXp3+ cells as well as lower numbers of CD8+ cells in
                      comparison with invasive cSCC. cSCC expressed significantly
                      more PD-L1 in comparison with AK and KA. Among cSCC PD-L1
                      expression was higher in moderately and
                      poorly-differentiated cSCC than in well-differentiated cSCC.
                      Increased PD-L1 expression also correlated with increased
                      numbers of CD4+, CD8+ and FOXp3+ cells in
                      cSCC.Tumor-associated T-lymphocyte infiltrates showed
                      significant differences between AK, KA and invasive cSCC.
                      PD-L1 expression correlated with invasion of T-cell
                      infiltrates in invasive cSCC.},
      cin          = {A190 / G300 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)G300-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29799076},
      doi          = {10.1007/s00262-018-2171-7},
      url          = {https://inrepo02.dkfz.de/record/136016},
}