%0 Journal Article
%A Klein, Carmen Doris
%A Dokic, Ivana
%A Mairani, Andrea
%A Mein, Stewart
%A Brons, Stephan
%A Häring, Peter
%A Haberer, Thomas
%A Jäkel, Oliver
%A Zimmermann, Astrid
%A Zenke, Frank
%A Blaukat, Andree
%A Debus, Jürgen
%A Abdollahi, Amir
%T Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.101
%J Radiation oncology
%V 12
%N 1
%@ 1748-717X
%C London
%I BioMed Central
%M DKFZ-2018-01116
%P 208
%D 2017
%X Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibitors of DNA-Damage Response (DDR) on tumor cell radiosensitivity under hypoxic conditions.Human non-small cell lung cancer (NSCLC) models, A549 and H1437, were irradiated with dose series of photon and carbon ions under hypoxia (1
%K Enzyme Inhibitors (NLM Chemicals)
%K Nuclear Proteins (NLM Chemicals)
%K Radiation-Sensitizing Agents (NLM Chemicals)
%K ATM protein, human (NLM Chemicals)
%K Ataxia Telangiectasia Mutated Proteins (NLM Chemicals)
%K DNA-Activated Protein Kinase (NLM Chemicals)
%K PRKDC protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29287602
%2 pmc:PMC5747947
%R 10.1186/s13014-017-0939-0
%U https://inrepo02.dkfz.de/record/136647