TY  - JOUR
AU  - Assi, Nada
AU  - Gunter, Marc J
AU  - Thomas, Duncan C
AU  - Leitzmann, Michael
AU  - Stepien, Magdalena
AU  - Chajès, Véronique
AU  - Philip, Thierry
AU  - Vineis, Paolo
AU  - Bamia, Christina
AU  - Boutron-Ruault, Marie-Christine
AU  - Sandanger, Torkjel M
AU  - Molinuevo, Amaia
AU  - Boshuizen, Hendriek
AU  - Sundkvist, Anneli
AU  - Kühn, Tilman
AU  - Travis, Ruth
AU  - Overvad, Kim
AU  - Riboli, Elio
AU  - Scalbert, Augustin
AU  - Jenab, Mazda
AU  - Viallon, Vivian
AU  - Ferrari, Pietro
TI  - Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort.
JO  - The American journal of clinical nutrition
VL  - 108
IS  - 1
SN  - 1938-3207
CY  - Bethesda, Md.
PB  - Soc.
M1  - DKFZ-2018-01124
SP  - 117-126
PY  - 2018
AB  - Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors.In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score. The association between the resulting PLS scores and HCC risk was examined in multivariable conditional logistic regression models, where ORs and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29924298
DO  - DOI:10.1093/ajcn/nqy074
UR  - https://inrepo02.dkfz.de/record/136655
ER  -