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000136670 1001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b0$$eFirst author
000136670 245__ $$aPractical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.
000136670 260__ $$aBerlin$$bSpringer$$c2018
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000136670 520__ $$aRecently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based central nervous system (CNS) tumor diagnostics conducted in our institution between the years 2015 and 2018. In this period, more than 1000 tumors from the neurosurgical departments in Heidelberg and Mannheim and more than 1000 tumors referred from external institutions were subjected to DNA methylation analysis for diagnostic purposes. We describe our current approach to the integrated diagnosis of CNS tumors with a focus on constellations with conflicts between morphological and molecular genetic findings. We further describe the benefit of integrating DNA copy-number alterations into diagnostic considerations and provide a catalog of copy-number changes for individual DNA methylation classes. We also point to several pitfalls accompanying the diagnostic implementation of DNA methylation profiling and give practical suggestions for recurring diagnostic scenarios.
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000136670 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b1
000136670 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b2
000136670 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b3
000136670 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b4
000136670 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b5$$udkfz
000136670 7001_ $$aSchmid, Simone$$b6
000136670 7001_ $$aHovestadt, Volker$$b7
000136670 7001_ $$0P:(DE-HGF)0$$aReuss, David E$$b8
000136670 7001_ $$0P:(DE-HGF)0$$aKoelsche, Christian$$b9
000136670 7001_ $$0P:(DE-HGF)0$$aReinhardt, Annekathrin$$b10
000136670 7001_ $$0P:(DE-HGF)0$$aWefers, Annika K$$b11
000136670 7001_ $$0P:(DE-HGF)0$$aHuang, Kristin$$b12
000136670 7001_ $$0P:(DE-HGF)0$$aSievers, Philipp$$b13
000136670 7001_ $$0P:(DE-HGF)0$$aEbrahimi, Azadeh$$b14
000136670 7001_ $$0P:(DE-HGF)0$$aSchöler, Anne$$b15
000136670 7001_ $$aTeichmann, Daniel$$b16
000136670 7001_ $$aKoch, Arend$$b17
000136670 7001_ $$aHänggi, Daniel$$b18
000136670 7001_ $$aUnterberg, Andreas$$b19
000136670 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b20
000136670 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b21
000136670 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b22
000136670 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b23
000136670 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b24
000136670 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b25
000136670 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b26$$eLast author
000136670 773__ $$0PERI:(DE-600)1458410-4$$a10.1007/s00401-018-1879-y$$gVol. 136, no. 2, p. 181 - 210$$n2$$p181 - 210$$tActa neuropathologica$$v136$$x1432-0533$$y2018
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