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@ARTICLE{Cramer:136676,
      author       = {D. W. Cramer and R. N. Fichorova and K. L. Terry and H.
                      Yamamoto and A. F. Vitonis and E. Ardanaz and D. Aune and H.
                      Boeing and J. Brändstedt and M.-C. Boutron-Ruault and M.-D.
                      Chirlaque and M. Dorronsoro and L. Dossus and E. J. Duell
                      and I. T. Gram and M. Gunter and L. Hansen and A. Idahl and
                      T. S. Johnson$^*$ and K.-T. Khaw and V. Krogh and M.
                      Kvaskoff and A. Mattiello and G. Matullo and M. A. Merritt
                      and B. Nodin and P. Orfanos and N. C. Onland-Moret and D.
                      Palli and E. Peppa and J. R. Quirós and M.-J.
                      Sánchez-Perez and G. Severi and A. Tjønneland and R. C.
                      Travis and A. Trichopoulou and R. Tumino and E. Weiderpass
                      and R. Turzanski-Fortner$^*$ and R. Kaaks$^*$},
      title        = {{A}nti-{CA}15.3 and {A}nti-{CA}125 {A}ntibodies and
                      {O}varian {C}ancer {R}isk: {R}esults from the {EPIC}
                      {C}ohort.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {27},
      number       = {7},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2018-01144},
      pages        = {790 - 804},
      year         = {2018},
      abstract     = {Background: Neoplastic and non-neoplastic events may raise
                      levels of mucins, CA15.3, and CA125, and generate antibodies
                      against them, but their impact on epithelial ovarian cancer
                      (EOC) risk has not been fully defined.Methods: CA15.3,
                      CA125, and IgG1 antibodies against them were measured in 806
                      women who developed EOC and 1,927 matched controls from the
                      European Prospective Investigation of Nutrition and Cancer.
                      Associations between epidemiologic factors and anti-mucin
                      antibodies were evaluated using generalized linear models;
                      EOC risks associated with anti-mucin antibodies, by
                      themselves or in combination with respective antigens, were
                      evaluated using conditional logistic regression.Results: In
                      controls, lower antibodies against both mucins were
                      associated with current smoking; and, in postmenopausal
                      women, higher levels with longer oral contraceptive use and
                      later-age-at and shorter-interval-since last birth. Lower
                      anti-CA15.3 antibodies were associated with higher body mass
                      and, in premenopausal women, more ovulatory cycles. Higher
                      anti-CA15.3 and anti-CA125 antibodies were associated with
                      higher risk for mucinous EOC occurring ≥ 3 years from
                      enrollment. Long-term risk for serous EOC was reduced in
                      women with low CA125 and high anti-CA125 antibodies relative
                      to women with low concentrations of both.Conclusions: We
                      found general support for the hypothesis that anti-mucin
                      antibody levels correlate with risk factors for EOC.
                      Antibodies alone or in combinations with their antigen may
                      predict longer term risk of specific EOC types.Impact:
                      Anti-CA125 and anti-CA15.3 antibodies alone or in
                      perspective of antigens may be informative in the
                      pathogenesis of EOC subtypes, but less useful for informing
                      risk for all EOC. Cancer Epidemiol Biomarkers Prev; 27(7);
                      790-804. ©2018 AACR.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29661801},
      doi          = {10.1158/1055-9965.EPI-17-0744},
      url          = {https://inrepo02.dkfz.de/record/136676},
}