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@ARTICLE{Erben:136711,
      author       = {V. Erben$^*$ and M. Bhardwaj$^*$ and P. Schrotz-King$^*$
                      and H. Brenner$^*$},
      title        = {{M}etabolomics {B}iomarkers for {D}etection of {C}olorectal
                      {N}eoplasms: {A} {S}ystematic {R}eview.},
      journal      = {Cancers},
      volume       = {10},
      number       = {8},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2018-01149},
      pages        = {246},
      year         = {2018},
      abstract     = {Several approaches have been suggested to be useful in the
                      early detection of colorectal neoplasms. Since metabolites
                      are closely related to the phenotype and are available from
                      different human bio-fluids, metabolomics are candidates for
                      non-invasive early detection of colorectal neoplasms.We
                      aimed to summarize current knowledge on performance
                      characteristics of metabolomics biomarkers that are
                      potentially applicable in a screening setting for the early
                      detection of colorectal neoplasms.We conducted a systematic
                      literature search in PubMed and Web of Science and searched
                      for biomarkers for the early detection of colorectal
                      neoplasms in easy-to-collect human bio-fluids. Information
                      on study design and performance characteristics for
                      diagnostic accuracy was extracted.Finally, we included 41
                      studies in our analysis investigating biomarkers in
                      different bio-fluids (blood, urine, and feces). Although
                      single metabolites mostly had limited ability to distinguish
                      people with and without colorectal neoplasms, promising
                      results were reported for metabolite panels, especially
                      amino acid panels in blood samples, as well as nucleosides
                      in urine samples in several studies. However, validation of
                      the results is limited.Panels of metabolites consisting of
                      amino acids in blood and nucleosides in urinary samples
                      might be useful biomarkers for early detection of advanced
                      colorectal neoplasms. However, to make metabolomic
                      biomarkers clinically applicable, future research in larger
                      studies and external validation of the results is required.},
      subtyp        = {Review Article},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30060469},
      doi          = {10.3390/cancers10080246},
      url          = {https://inrepo02.dkfz.de/record/136711},
}